Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

Andres Acosta, Michael Camilleri, Andrea Shin, Paula Carlson, Duane Burton, Jessica O'Neill, Deborah Eckert, Alan R. Zinsmeister

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Melanocortin 4 receptor (MC4R) has a major role in energy homeostasis. The rs17782313 polymorphism, mapped 188 kb downstream from MC4R, has been associated with satiety, higher body mass index (BMI) and total calorie intake in adults. To assess the association of rs17782313 with gastric functions, satiation, or satiety, we studied 178 predominantly Caucasian overweight and obese people: 120 females, 58 males; mean BMI 33.4 ± 5.3 kg/m2 (SD); age 37.7 ± 11.2 years. Quantitative traits assessed were gastric emptying (GE) of solids and liquids; fasting and postprandial gastric volume; satiation by maximum tolerated volume and 4 symptoms by 100-mm visual analog scales (VAS); and satiety by ad libitum buffet meal. Associations of genotype and quantitative traits were assessed by analysis of covariance (using gender and BMI as covariates), based on a dominant [TC (n = 72) - CC (n = 12) vs. TT (n = 94)] genetic model. rs17782313(C) was associated with postprandial satiation symptoms (median Δ total VAS 26.5 mm, p = 0.036), reduced proportion of solid GE at 2 h (median Δ 6.7%, p = 0.008) and 4 h (median Δ 3.2%, p = 0.006), and longer t1/2 (median Δ 6 min, p = 0.034). Associations of rs17782313 with obesity may be explained by reduced satiation and GE. The role of MC4R mechanisms in satiation and gastric function deserves further study.

Original languageEnglish (US)
Article number384
JournalGenes and Nutrition
Volume9
Issue number2
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • Gastric emptying
  • Melanocortin 4 receptor (MC4R)
  • Obesity
  • Satiation
  • rs17782313

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

Fingerprint Dive into the research topics of 'Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults'. Together they form a unique fingerprint.

Cite this