Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders

R. M. Bowler, C. L. Yeh, S. W. Adams, E. J. Ward, R. E. Ma, S. Dharmadhikari, S. A. Snyder, S. Zauber, C. W. Wright, U. Dydak

Research output: Contribution to journalArticle

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Abstract

This study examines the results of neuropsychological testing of 26 active welders and 17 similar controls and their relationship to welders' shortened MRI T1 relaxation time, indicative of increased brain manganese (Mn) accumulation. Welders were exposed to Mn for an average duration of 12.25 years to average levels of Mn in air of 0.11±0.05mg/m3. Welders scored significantly worse than controls on Fruit Naming and the Parallel Lines test of graphomotor tremor. Welders had shorter MRI T1 relaxation times than controls in the globus pallidus, substantia nigra, caudate nucleus, and the anterior prefrontal lobe. 63% of the variation in MRI T1 relaxation times was accounted for by exposure group. In welders, lower relaxation times in the caudate nucleus and substantia nigra were associated with lower neuropsychological test performance on tests of verbal fluency (Fruit Naming), verbal learning, memory, and perseveration (WHO-UCLA AVLT). Results indicate that verbal function may be one of the first cognitive domains affected by brain Mn deposition in welders as reflected by MRI T1 relaxation times.

Original languageEnglish (US)
JournalNeuroToxicology
DOIs
StateAccepted/In press - Aug 12 2016

Fingerprint

Neuropsychological Tests
Manganese
Magnetic resonance imaging
Relaxation time
Caudate Nucleus
Substantia Nigra
Fruits
Fruit
Brain
Verbal Learning
Globus Pallidus
Tremor
Air
Data storage equipment
Testing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Bowler, R. M., Yeh, C. L., Adams, S. W., Ward, E. J., Ma, R. E., Dharmadhikari, S., ... Dydak, U. (Accepted/In press). Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders. NeuroToxicology. https://doi.org/10.1016/j.neuro.2017.05.010

Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders. / Bowler, R. M.; Yeh, C. L.; Adams, S. W.; Ward, E. J.; Ma, R. E.; Dharmadhikari, S.; Snyder, S. A.; Zauber, S.; Wright, C. W.; Dydak, U.

In: NeuroToxicology, 12.08.2016.

Research output: Contribution to journalArticle

Bowler, R. M. ; Yeh, C. L. ; Adams, S. W. ; Ward, E. J. ; Ma, R. E. ; Dharmadhikari, S. ; Snyder, S. A. ; Zauber, S. ; Wright, C. W. ; Dydak, U. / Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders. In: NeuroToxicology. 2016.
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