Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder

Dean F. MacKinnon, Peter P. Zandi, Elliot S. Gershon, John Nurnberger, J. Raymond DePaulo

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective: Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder. Method: Six hundred six subjects with bipolar disorder from the NIMH Bipolar Disorder Genetics Initiative were included in the study. Logistic regression analysis was used to analyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for panic. Results: Familial panic and the diagnosis of panic disorder in an individual subject increased the odds for rapid mood switching. The familial effect persisted when individuals with panic disorder were excluded from the analysis. Conclusions: Panic and rapid mood switching occurring together in familial bipolar disorder may define a useful subphenotype for future studies.

Original languageEnglish (US)
Pages (from-to)1696-1698
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number9
DOIs
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Panic
Panic Disorder
Bipolar Disorder
National Institute of Mental Health (U.S.)
Comorbidity
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder. / MacKinnon, Dean F.; Zandi, Peter P.; Gershon, Elliot S.; Nurnberger, John; DePaulo, J. Raymond.

In: American Journal of Psychiatry, Vol. 160, No. 9, 09.2003, p. 1696-1698.

Research output: Contribution to journalArticle

MacKinnon, Dean F. ; Zandi, Peter P. ; Gershon, Elliot S. ; Nurnberger, John ; DePaulo, J. Raymond. / Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder. In: American Journal of Psychiatry. 2003 ; Vol. 160, No. 9. pp. 1696-1698.
@article{d1c56ed85c324f24960ba23082d468e2,
title = "Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder",
abstract = "Objective: Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder. Method: Six hundred six subjects with bipolar disorder from the NIMH Bipolar Disorder Genetics Initiative were included in the study. Logistic regression analysis was used to analyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for panic. Results: Familial panic and the diagnosis of panic disorder in an individual subject increased the odds for rapid mood switching. The familial effect persisted when individuals with panic disorder were excluded from the analysis. Conclusions: Panic and rapid mood switching occurring together in familial bipolar disorder may define a useful subphenotype for future studies.",
author = "MacKinnon, {Dean F.} and Zandi, {Peter P.} and Gershon, {Elliot S.} and John Nurnberger and DePaulo, {J. Raymond}",
year = "2003",
month = "9",
doi = "10.1176/appi.ajp.160.9.1696",
language = "English (US)",
volume = "160",
pages = "1696--1698",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "9",

}

TY - JOUR

T1 - Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder

AU - MacKinnon, Dean F.

AU - Zandi, Peter P.

AU - Gershon, Elliot S.

AU - Nurnberger, John

AU - DePaulo, J. Raymond

PY - 2003/9

Y1 - 2003/9

N2 - Objective: Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder. Method: Six hundred six subjects with bipolar disorder from the NIMH Bipolar Disorder Genetics Initiative were included in the study. Logistic regression analysis was used to analyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for panic. Results: Familial panic and the diagnosis of panic disorder in an individual subject increased the odds for rapid mood switching. The familial effect persisted when individuals with panic disorder were excluded from the analysis. Conclusions: Panic and rapid mood switching occurring together in familial bipolar disorder may define a useful subphenotype for future studies.

AB - Objective: Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder. Method: Six hundred six subjects with bipolar disorder from the NIMH Bipolar Disorder Genetics Initiative were included in the study. Logistic regression analysis was used to analyze rapid mood switching as a function of panic disorder diagnosis, sex, and familial risk for panic. Results: Familial panic and the diagnosis of panic disorder in an individual subject increased the odds for rapid mood switching. The familial effect persisted when individuals with panic disorder were excluded from the analysis. Conclusions: Panic and rapid mood switching occurring together in familial bipolar disorder may define a useful subphenotype for future studies.

UR - http://www.scopus.com/inward/record.url?scp=0642374518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642374518&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.160.9.1696

DO - 10.1176/appi.ajp.160.9.1696

M3 - Article

C2 - 12944349

AN - SCOPUS:0642374518

VL - 160

SP - 1696

EP - 1698

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 9

ER -