Association of resistin promoter polymorphisms with plasma resistin levels and type 2 diabetes in women and men

Brian H. Chen, Yiqing Song, Eric L. Ding, Joann E. Manson, Christian K. Roberts, Nader Rifai, Julie E. Buring, J. Michael Gaziano, Simin Liu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This study's objective was to examine the associations between resistin (RETN) polymorphisms, plasma resistin levels, and type 2 diabetes risk. We conducted two nested case-control studies in postmenopausal women (359 incident cases and 359 controls) and middle-aged/elderly men (170 incident cases and 170 controls). Controls were matched (1:1) to cases by age, race, duration of follow-up, and time of blood draw. Circulating resistin levels were higher among carriers of the variant allele for rs34861192 (p<0.0001 for women, p=0.002 for men) but not rs1862513 (p=0.15 for women, p=0.14 for men). Neither polymorphism was significantly associated with risk of type 2 diabetes after adjusting for diabetes risk factors (exercise, smoking status, alcohol intake, family history of diabetes, and matching factors) among women (rs1862513: OR=1.19, 95% CI=0.80-1.77; rs34861192: OR=0.41, 95% CI=0.14-1.19) and men (rs1862513: OR=1.05, 95% CI=0.57-1.95; rs34861192: OR=0.64, 95% CI=0.14-2.89). In conclusion, RETN promoter polymorphism rs34861192 was associated with elevated circulating resistin levels, but rs1862513 was not. Neither polymorphism was associated with an increased risk for type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalInternational Journal of Molecular Epidemiology and Genetics
Volume1
Issue number3
StatePublished - Aug 23 2010
Externally publishedYes

Keywords

  • BMI
  • CRP
  • RETN
  • Resistin
  • TNFα-RII
  • Type 2 diabetes

ASJC Scopus subject areas

  • Epidemiology
  • Genetics
  • Genetics(clinical)

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  • Cite this

    Chen, B. H., Song, Y., Ding, E. L., Manson, J. E., Roberts, C. K., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2010). Association of resistin promoter polymorphisms with plasma resistin levels and type 2 diabetes in women and men. International Journal of Molecular Epidemiology and Genetics, 1(3), 167-174.