Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans

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Abstract

In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI"D"), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI"D".

Original languageEnglish
Pages (from-to)266-271
Number of pages6
JournalEthnicity and Disease
Volume6
Issue number3-4
StatePublished - Sep 1996

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Apolipoprotein E4
African Americans
Dementia
Alleles
Odds Ratio
Apolipoproteins E
Alzheimer Disease
Genotype
Population

Keywords

  • African Americans and Community Survey
  • APOE
  • Apolipoprotein E
  • Cognitive Function
  • Dementia

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

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title = "Association of the ε4 allele of apolipoprotein E with poor performance on a dementia screen in African Americans",
abstract = "In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI{"}D{"}), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95{\%} CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95{\%} CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI{"}D{"}.",
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AU - Hui, Siu

AU - Gao, Sujuan

AU - Hall, Kathleen

AU - Sahota, Amrik

AU - Hendrie, Hugh

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AB - In a community-based study of Alzheimer's disease in African Americans age 65 and over, subjects were classified into three levels of performance based on their scores as measured by the Community Screening Instrument for Dementia (CSI"D"), consisting of cognitive and functioning components. In a subset of 268 subjects with apolipoprotein E (APOE) genotype data, we found that the ε4 allele of APOE was associated with intermediate/poor performance (single copy ε4 odds ratio 1.51, 95% CI 1.18 to 1.92; double copy ε4 odds ratio 3.42, 95% CI 2.18 to 5.43). From these data, we believe it would be possible to conduct population screening for the effects of possession of the APOE-ε4 allele using information derived from the CSI"D".

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