Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in african-americans

Jeesun Jung, Tatiana Foroud, George J. Eckert, Leah Flury-Wetherill, Howard Edenberg, Xiaoling Xuei, Syed Adeel Zaidi, J. Howard Pratt

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Context: Calcium binding to the Ca-sensing receptor (CASR) expressed in thick ascending limb inhibits the Na,K,2CI cotransporter, which decreases sodium reabsorption and secondarily decreases Ca reab-sorption. CASR gene variants could influence blood pressure (BP) by affecting Na retention.Objective: The objective of the study was to determine whether variations in CASR associated with BP in African-Americans, an ethnic group at high risk for hypertension.Design: Population-and family-based association studies of single-nucleotide polymorphisms (SNPs) in CASR with BP measured over the age range 5.6-25 yr (14 biannual visits per subject on average) were carried out. In a cross-sectional study where urinary Ca excretion had been measured, Ca excretion was used as an additional phenotype of CASR influence on Na,K,2CI cotransporter activity.Participants: Subjects were normotensive. In the longitudinal study, there were 223 subjects (mean age 14 yr) and 123 families (one or both parents provided a DNA sample); in the cross-sectional study, there were 106 subjects (mean age 23 yr) and 88 families.Results: Three SNPs in linkage disequilibrium associated with systolic BP at P < 0.005 (the significance threshold corrected for multiple comparisons) in the population-based longitudinal study. In the cross-sectional study, SNPs contained in the same linkage disequilibrium block associated with urinary Ca excretion in both population- and family-based association tudies.Conclusion: The findings suggestthat in African-Americans, functional heterogeneity of the CASR.

Original languageEnglish
Pages (from-to)1042-1048
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number3
DOIs
StatePublished - Mar 2009

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Calcium-Sensing Receptors
Blood pressure
African Americans
Genes
Blood Pressure
Calcium
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Cross-Sectional Studies
Linkage Disequilibrium
Longitudinal Studies
Population
Ethnic Groups
Sorption
Extremities
Parents
Sodium
Hypertension
Phenotype

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in african-americans. / Jung, Jeesun; Foroud, Tatiana; Eckert, George J.; Flury-Wetherill, Leah; Edenberg, Howard; Xuei, Xiaoling; Zaidi, Syed Adeel; Pratt, J. Howard.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 3, 03.2009, p. 1042-1048.

Research output: Contribution to journalArticle

Jung, Jeesun ; Foroud, Tatiana ; Eckert, George J. ; Flury-Wetherill, Leah ; Edenberg, Howard ; Xuei, Xiaoling ; Zaidi, Syed Adeel ; Pratt, J. Howard. / Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in african-americans. In: Journal of Clinical Endocrinology and Metabolism. 2009 ; Vol. 94, No. 3. pp. 1042-1048.
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