Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family

Gary W. Reuther, Haian Fu, Larry Cripe, R. John Collier, Ann Marie Pendergast

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

In this study, a protein that interacts with sequences encoded by the first exon of the protein kinase Bcr was cloned. The Bcr-associated protein 1 (Bap-1) is a member of the 14-3-3 family of proteins. Bap-1 interacts with full-length c-Bcr and with the chimeric Bcr-Abl tyrosine kinase of Philadelphia chromosome (Ph1)-positive human leukemias. Bap-1 is a substrate for the Bcr serine-threonine kinase and is also phosphorylated on tyrosine by Bcr-Abl but not by c-Abl. Bap-1 may function in the regulation of c-Bcr and may contribute to the transforming activity of Bcr-Abl in vivo. 14-3-3 proteins are essential for cell proliferation and have a role in determining the timing of mitosis in yeast. Through direct binding to sequences present in Bcr and in other proteins implicated in signaling, the mammalian 14-3-3 proteins may link specific signaling protein components to mitogenic and cell-cycle control pathways.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalScience
Volume266
Issue number5182
StatePublished - Oct 7 1994
Externally publishedYes

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14-3-3 Proteins
Protein Kinases
Proteins
bcr-abl Fusion Proteins
Philadelphia Chromosome
Protein-Serine-Threonine Kinases
Cell Cycle Checkpoints
Mitosis
Tyrosine
Exons
Leukemia
Yeasts
Cell Proliferation

ASJC Scopus subject areas

  • General

Cite this

Reuther, G. W., Fu, H., Cripe, L., Collier, R. J., & Pendergast, A. M. (1994). Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. Science, 266(5182), 129-133.

Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. / Reuther, Gary W.; Fu, Haian; Cripe, Larry; Collier, R. John; Pendergast, Ann Marie.

In: Science, Vol. 266, No. 5182, 07.10.1994, p. 129-133.

Research output: Contribution to journalArticle

Reuther, GW, Fu, H, Cripe, L, Collier, RJ & Pendergast, AM 1994, 'Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family', Science, vol. 266, no. 5182, pp. 129-133.
Reuther GW, Fu H, Cripe L, Collier RJ, Pendergast AM. Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. Science. 1994 Oct 7;266(5182):129-133.
Reuther, Gary W. ; Fu, Haian ; Cripe, Larry ; Collier, R. John ; Pendergast, Ann Marie. / Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. In: Science. 1994 ; Vol. 266, No. 5182. pp. 129-133.
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