Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States

Kelly Virecoulon Giudici, Joseph M. Kindler, Berdine R. Martin, Emma M. Laing, George P. McCabe, Linda D. McCabe, Dorothy B. Hausman, Lígia Araújo Martini, Richard D. Lewis, Connie M. Weaver, Munro Peacock, Kathleen M. Hill Gallant

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. Methods: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed. Results: Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; p = 0.04) and glucose (partial r = -0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all p < 0.001). Conclusions: These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported. Clinical trial registration number: NCT00931580.

Original languageEnglish (US)
Article number25
JournalNutrition and Metabolism
Volume14
Issue number1
DOIs
StatePublished - Mar 7 2017

Fingerprint

Osteocalcin
Leptin
Adipose Tissue
Glucose
Serum
Fasting
Health
Insulin
Child Health
Vitamin D
Energy Metabolism
Randomized Controlled Trials
Cross-Sectional Studies
Fats
Placebos
Clinical Trials

Keywords

  • Children
  • Glucose
  • Insulin
  • Leptin
  • Obesity
  • Osteocalcin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Giudici, K. V., Kindler, J. M., Martin, B. R., Laing, E. M., McCabe, G. P., McCabe, L. D., ... Hill Gallant, K. M. (2017). Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. Nutrition and Metabolism, 14(1), [25]. https://doi.org/10.1186/s12986-017-0171-9

Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. / Giudici, Kelly Virecoulon; Kindler, Joseph M.; Martin, Berdine R.; Laing, Emma M.; McCabe, George P.; McCabe, Linda D.; Hausman, Dorothy B.; Martini, Lígia Araújo; Lewis, Richard D.; Weaver, Connie M.; Peacock, Munro; Hill Gallant, Kathleen M.

In: Nutrition and Metabolism, Vol. 14, No. 1, 25, 07.03.2017.

Research output: Contribution to journalArticle

Giudici, KV, Kindler, JM, Martin, BR, Laing, EM, McCabe, GP, McCabe, LD, Hausman, DB, Martini, LA, Lewis, RD, Weaver, CM, Peacock, M & Hill Gallant, KM 2017, 'Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States', Nutrition and Metabolism, vol. 14, no. 1, 25. https://doi.org/10.1186/s12986-017-0171-9
Giudici, Kelly Virecoulon ; Kindler, Joseph M. ; Martin, Berdine R. ; Laing, Emma M. ; McCabe, George P. ; McCabe, Linda D. ; Hausman, Dorothy B. ; Martini, Lígia Araújo ; Lewis, Richard D. ; Weaver, Connie M. ; Peacock, Munro ; Hill Gallant, Kathleen M. / Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. In: Nutrition and Metabolism. 2017 ; Vol. 14, No. 1.
@article{dfad72f33c7e452295d4ed07aafad989,
title = "Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States",
abstract = "Background: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. Methods: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed. Results: Approximately 52{\%} of study participants were obese based on percent body fat cutoffs (>25{\%} for boys and >32{\%} for girls) and about 5{\%} had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; p = 0.04) and glucose (partial r = -0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all p < 0.001). Conclusions: These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported. Clinical trial registration number: NCT00931580.",
keywords = "Children, Glucose, Insulin, Leptin, Obesity, Osteocalcin",
author = "Giudici, {Kelly Virecoulon} and Kindler, {Joseph M.} and Martin, {Berdine R.} and Laing, {Emma M.} and McCabe, {George P.} and McCabe, {Linda D.} and Hausman, {Dorothy B.} and Martini, {L{\'i}gia Ara{\'u}jo} and Lewis, {Richard D.} and Weaver, {Connie M.} and Munro Peacock and {Hill Gallant}, {Kathleen M.}",
year = "2017",
month = "3",
day = "7",
doi = "10.1186/s12986-017-0171-9",
language = "English (US)",
volume = "14",
journal = "Nutrition and Metabolism",
issn = "1743-7075",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States

AU - Giudici, Kelly Virecoulon

AU - Kindler, Joseph M.

AU - Martin, Berdine R.

AU - Laing, Emma M.

AU - McCabe, George P.

AU - McCabe, Linda D.

AU - Hausman, Dorothy B.

AU - Martini, Lígia Araújo

AU - Lewis, Richard D.

AU - Weaver, Connie M.

AU - Peacock, Munro

AU - Hill Gallant, Kathleen M.

PY - 2017/3/7

Y1 - 2017/3/7

N2 - Background: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. Methods: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed. Results: Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; p = 0.04) and glucose (partial r = -0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all p < 0.001). Conclusions: These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported. Clinical trial registration number: NCT00931580.

AB - Background: This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years. Methods: This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed. Results: Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; p = 0.04) and glucose (partial r = -0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all p < 0.001). Conclusions: These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported. Clinical trial registration number: NCT00931580.

KW - Children

KW - Glucose

KW - Insulin

KW - Leptin

KW - Obesity

KW - Osteocalcin

UR - http://www.scopus.com/inward/record.url?scp=85014604344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014604344&partnerID=8YFLogxK

U2 - 10.1186/s12986-017-0171-9

DO - 10.1186/s12986-017-0171-9

M3 - Article

AN - SCOPUS:85014604344

VL - 14

JO - Nutrition and Metabolism

JF - Nutrition and Metabolism

SN - 1743-7075

IS - 1

M1 - 25

ER -