Associations between diet, lifestyle factors, and telomere length in women

Aedín Cassidy, Immaculata De Vivo, Yan Liu, Jiali Han, Jennifer Prescott, David J. Hunter, Eric B. Rimm

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Background: Leukocyte telomere length is associated with diseases of aging, but there is limited knowledge of diet and lifestyle determinants. Objective: The objective was to examine cross-sectionally the association between diet, body composition, and lifestyle factors on leukocyte telomere length in women. Design: Leukocyte telomere length was measured by quantitative polymerase chain reaction in 2284 female participants from the Nurses' Health Study, who were selected as controls for an investigation of biological predictors of cancer. Diet, lifestyle, and anthropometric data were assessed by questionnaire. Results: After multivariate adjustment, dietary fiber intake was positively associated with telomere length (z score), specifically cereal fiber, with an increase of 0.19 units between the lowest and highest quintiles (P = 0.007, P for trend = 0.03). Although total fat intake was not associated with telomere length, polyunsaturated fatty acid intake (-0.26 units, quintile 5 compared with quintile 1: P = 0.002, P for trend = 0.02), specifically linoleic acid intake, was inversely associated with telomere length after multivariate adjustment (-0.32 units; P = 0.001, P for trend = 0.05). Waist circumference was inversely associated with telomere length [0.15-unit difference in z score in a comparison of the highest (≥32 in, 81.28 cm) with the lowest (≤28 in, 71.12 cm) category (P = 0.01, P for trend = 0.02) in the multivariate model]. We found no association between telomere length and smoking, physical activity, or postmenopausal hormone use. Conclusion: Although the strength of the associations was modest in this population of middle- and older-age women, our results support the hypothesis that body composition and dietary factors are related to leukocyte telomere length, which is a potential biomarker of chronic disease risk.

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume91
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Telomere
Life Style
Diet
Leukocytes
Social Adjustment
Body Composition
Dietary Fiber
Waist Circumference
Linoleic Acid
Unsaturated Fatty Acids
Chronic Disease
Biomarkers
Smoking
Fats
Nurses
Hormones
Exercise
Polymerase Chain Reaction
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cassidy, A., De Vivo, I., Liu, Y., Han, J., Prescott, J., Hunter, D. J., & Rimm, E. B. (2010). Associations between diet, lifestyle factors, and telomere length in women. American Journal of Clinical Nutrition, 91(5), 1273-1280. https://doi.org/10.3945/ajcn.2009.28947

Associations between diet, lifestyle factors, and telomere length in women. / Cassidy, Aedín; De Vivo, Immaculata; Liu, Yan; Han, Jiali; Prescott, Jennifer; Hunter, David J.; Rimm, Eric B.

In: American Journal of Clinical Nutrition, Vol. 91, No. 5, 01.05.2010, p. 1273-1280.

Research output: Contribution to journalArticle

Cassidy, A, De Vivo, I, Liu, Y, Han, J, Prescott, J, Hunter, DJ & Rimm, EB 2010, 'Associations between diet, lifestyle factors, and telomere length in women', American Journal of Clinical Nutrition, vol. 91, no. 5, pp. 1273-1280. https://doi.org/10.3945/ajcn.2009.28947
Cassidy, Aedín ; De Vivo, Immaculata ; Liu, Yan ; Han, Jiali ; Prescott, Jennifer ; Hunter, David J. ; Rimm, Eric B. / Associations between diet, lifestyle factors, and telomere length in women. In: American Journal of Clinical Nutrition. 2010 ; Vol. 91, No. 5. pp. 1273-1280.
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