Associations between menarche-related genetic variants and pubertal growth in male and female adolescents

Wanzhu Tu, Erin K. Wagner, George J. Eckert, Zhangsheng Yu, Tamara Hannon, J. Howard Pratt, Chunyan He

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.

Methods We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect models.

Results Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤.0032), but none of them was associated with changes in height. Of the eight menarche-timing and BMI-related SNPs, none was associated with changes in height, but three (in or near genes NEGR1, ETV5, and FTO) were associated with more rapid increases in weight and/or BMI in EA (p ≤0059). Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ 0042).

Conclusions Genetic variants related to age at menarche were found to be associated with various growth parameters in healthy adolescents. The identified associations were often race and sex specific.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalJournal of Adolescent Health
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Menarche
Single Nucleotide Polymorphism
Body Mass Index
Growth
African Americans
Weights and Measures
Genes

Keywords

  • Age at menarche
  • Genetic variants
  • Growth
  • Puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Public Health, Environmental and Occupational Health

Cite this

Associations between menarche-related genetic variants and pubertal growth in male and female adolescents. / Tu, Wanzhu; Wagner, Erin K.; Eckert, George J.; Yu, Zhangsheng; Hannon, Tamara; Pratt, J. Howard; He, Chunyan.

In: Journal of Adolescent Health, Vol. 56, No. 1, 01.01.2015, p. 66-72.

Research output: Contribution to journalArticle

@article{87811e6d0a82470890c5aed67b2e23c5,
title = "Associations between menarche-related genetic variants and pubertal growth in male and female adolescents",
abstract = "Purpose Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.Methods We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect models.Results Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤.0032), but none of them was associated with changes in height. Of the eight menarche-timing and BMI-related SNPs, none was associated with changes in height, but three (in or near genes NEGR1, ETV5, and FTO) were associated with more rapid increases in weight and/or BMI in EA (p ≤0059). Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ 0042).Conclusions Genetic variants related to age at menarche were found to be associated with various growth parameters in healthy adolescents. The identified associations were often race and sex specific.",
keywords = "Age at menarche, Genetic variants, Growth, Puberty",
author = "Wanzhu Tu and Wagner, {Erin K.} and Eckert, {George J.} and Zhangsheng Yu and Tamara Hannon and Pratt, {J. Howard} and Chunyan He",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.jadohealth.2014.07.020",
language = "English",
volume = "56",
pages = "66--72",
journal = "Journal of Adolescent Health",
issn = "1054-139X",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Associations between menarche-related genetic variants and pubertal growth in male and female adolescents

AU - Tu, Wanzhu

AU - Wagner, Erin K.

AU - Eckert, George J.

AU - Yu, Zhangsheng

AU - Hannon, Tamara

AU - Pratt, J. Howard

AU - He, Chunyan

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.Methods We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect models.Results Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤.0032), but none of them was associated with changes in height. Of the eight menarche-timing and BMI-related SNPs, none was associated with changes in height, but three (in or near genes NEGR1, ETV5, and FTO) were associated with more rapid increases in weight and/or BMI in EA (p ≤0059). Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ 0042).Conclusions Genetic variants related to age at menarche were found to be associated with various growth parameters in healthy adolescents. The identified associations were often race and sex specific.

AB - Purpose Previous studies have identified novel genetic variants associated with age at menarche in females of European descent. The pubertal growth effects of these variants have not been carefully evaluated in non-European descent groups. We aimed to examine the effects of 31 newly identified menarche-related single-nucleotide polymorphisms (SNPs) on growth outcomes in African-American (AA) and European-American (EA) children in a prospective cohort.Methods We analyzed longitudinal data collected from 263 AAs and 338 EAs enrolled between ages 5 and 17 years; the subjects were followed semiannually for an average of 6 years. The associations between the SNPs and growth-related outcomes, including weight, height, and body mass index (BMI), were examined using mixed-effect models.Results Longitudinal analyses revealed that 4 (near or in genes VGLL3, PEX2, CA10, and SKOR2) of the 14 menarche-only-related SNPs were associated with changes in weight and BMI in EA and AA (p ≤.0032), but none of them was associated with changes in height. Of the eight menarche-timing and BMI-related SNPs, none was associated with changes in height, but three (in or near genes NEGR1, ETV5, and FTO) were associated with more rapid increases in weight and/or BMI in EA (p ≤0059). Among the nine menarche-timing and height-related SNPs, four (in or near genes ZBTB38, LOC728666, TBX2, and CABLES) were associated with changes in weight or height in EA and AA (p ≤ 0042).Conclusions Genetic variants related to age at menarche were found to be associated with various growth parameters in healthy adolescents. The identified associations were often race and sex specific.

KW - Age at menarche

KW - Genetic variants

KW - Growth

KW - Puberty

UR - http://www.scopus.com/inward/record.url?scp=84919435845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919435845&partnerID=8YFLogxK

U2 - 10.1016/j.jadohealth.2014.07.020

DO - 10.1016/j.jadohealth.2014.07.020

M3 - Article

C2 - 25287989

AN - SCOPUS:84919435845

VL - 56

SP - 66

EP - 72

JO - Journal of Adolescent Health

JF - Journal of Adolescent Health

SN - 1054-139X

IS - 1

ER -