Associations between rotating night shifts, sleep duration, and telomere length in women

Geyu Liang, Eva Schernhammer, Lu Qi, Xiang Gao, Immaculata de Vivo, Jiali Han

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background: Telomere length has been proposed as a marker of aging. However, our knowledge of lifestyle risk factors determining telomere length is limited. Methods: We evaluated the associations between years of rotating night shifts, self-reported sleep duration, and telomere length in 4,117 female participants from the Nurses' Health Study. Telomere length in peripheral blood leukocytes was determined by Real-Time PCR assay. Information on rotating night shifts and sleep duration was collected via questionnaires prior to blood collection. We used multivariable linear regression to investigate the associations between rotating night shifts, sleep duration, and telomere length. Results: Compared with women in the category (9 hours), those in the lowest category of sleep duration (≤6 hours) had a 0.12 unit decrease in z score after adjustment for age, BMI and cigarette smoking (equivalent to 9-year telomere attrition, P for trend = 0.05). Significant positive association between sleep duration and telomere length was seen among women under age of 50 (P for trend = 0.004), but not among those over 50 (P for trend = 0.33) (P for interaction = 0.005). In addition, we observed that women with a longer history of rotating night shifts tended to have shorter telomere length, but this relation was not statistically significant (P for trend = 0.36). Conclusion: We found that sleep duration was positively associated with telomere length among women under 50 years old. Further research is needed to confirm the observed associations.

Original languageEnglish (US)
Article numbere23462
JournalPLoS One
Volume6
Issue number8
DOIs
StatePublished - Aug 15 2011
Externally publishedYes

Fingerprint

telomeres
Telomere
sleep
Sleep
duration
Blood
Linear regression
Tobacco Products
Assays
smoking (habit)
Aging of materials
blood
Health
Association reactions
nurses
lifestyle
Life Style
Real-Time Polymerase Chain Reaction
Linear Models
leukocytes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Associations between rotating night shifts, sleep duration, and telomere length in women. / Liang, Geyu; Schernhammer, Eva; Qi, Lu; Gao, Xiang; de Vivo, Immaculata; Han, Jiali.

In: PLoS One, Vol. 6, No. 8, e23462, 15.08.2011.

Research output: Contribution to journalArticle

Liang, Geyu ; Schernhammer, Eva ; Qi, Lu ; Gao, Xiang ; de Vivo, Immaculata ; Han, Jiali. / Associations between rotating night shifts, sleep duration, and telomere length in women. In: PLoS One. 2011 ; Vol. 6, No. 8.
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