Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population

Xiaoxia Li, Yi Zhao, Yanan Jin, Tianjing Zhang, Xiaoyu Chang, Sha Liao, Hongxia Xu, Xiuying Liu, Jianjun Yang, Jianjun Zhang , Yuhong Zhang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although experimental studies have shown that adiponectin and leptin modulate glucose tolerance and insulin resistance, it remains unclear whether these adipocytokines exert similar effects in general human populations. We evaluated the associations of serum adiponectin and leptin with β-cell function and insulin resistance in a population with low obesity prevalence. A cross-sectional study of 783 rural residents, aged 25–74 years, recruited in Ningxia, China was conducted during 2008–2012. β-cell function and insulin resistance were estimated using the Homeostasis Model Assessment. Serum adiponectin and leptin were measured with ELISA. Serum adiponectin concentrations (mean ± SD) were highest in subjects with normal glucose tolerance (36.65 ± 61.13 μg/ml), intermediate in those with impaired fasting glucose (25.92 ± 34.48 μg/ml), and lowest in those with diabetes (15.08 ± 12.14 μg/ml) (p = 0.001). A similar pattern of differences was found for β-cell function, whereas opposite results were observed for insulin resistance and blood glucose. After adjustment for confounders including metabolic syndrome components, serum adiponectin (μg/ml) was inversely associated with β-cell function (%β) [β (95% CI): -7.57 (-12.33, -2.81)] and insulin resistance (100/%S) [β (95% CI): -0.21 (-0.33, -0.09)]. A significant inverse association also existed between serum leptin and β-cell function, but serum leptin was not significantly associated with insulin resistance. The present study suggests that adiponectin and leptin play a role in the development of insulin resistance and diabetes independent of metabolic syndrome.

Original languageEnglish (US)
Article numbere0182273
JournalPLoS One
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2017

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adipokines
Adipokines
Biomarkers
Rural Population
adiponectin
insulin resistance
Adiponectin
Leptin
Insulin Resistance
leptin
biomarkers
Insulin
Serum
metabolic syndrome
glucose tolerance
Medical problems
Glucose
cells
diabetes
China

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population. / Li, Xiaoxia; Zhao, Yi; Jin, Yanan; Zhang, Tianjing; Chang, Xiaoyu; Liao, Sha; Xu, Hongxia; Liu, Xiuying; Yang, Jianjun; Zhang , Jianjun; Zhang, Yuhong.

In: PLoS One, Vol. 12, No. 8, e0182273, 01.08.2017.

Research output: Contribution to journalArticle

Li, X, Zhao, Y, Jin, Y, Zhang, T, Chang, X, Liao, S, Xu, H, Liu, X, Yang, J, Zhang , J & Zhang, Y 2017, 'Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population', PLoS One, vol. 12, no. 8, e0182273. https://doi.org/10.1371/journal.pone.0182273
Li, Xiaoxia ; Zhao, Yi ; Jin, Yanan ; Zhang, Tianjing ; Chang, Xiaoyu ; Liao, Sha ; Xu, Hongxia ; Liu, Xiuying ; Yang, Jianjun ; Zhang , Jianjun ; Zhang, Yuhong. / Associations between serum adipocytokines and glycemic tolerance biomarkers in a rural Chinese population. In: PLoS One. 2017 ; Vol. 12, No. 8.
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