Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men

Lu Wang, Luc Djousse, Yiqing Song, Akintunde O. Akinkuolie, Chisa Matsumoto, Joann E. Manson, J. Michael Gaziano, Howard D. Sesso

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background. The associations of diabetes and obesity with the risk of abdominal aortic aneurysm (AAA) are inconclusive in previous studies. Subjects/Methods. We conducted prospective analysis in the Physicians' Health Study. Among 25,554 male physicians aged ≥ 50 years who reported no AAA at baseline, 471 reported a newly diagnosed AAA during a mean of 10.4 years' follow-up. Results. Compared with men who had baseline body mass index (BMI) < 25 kg/m2, the multivariable hazard ratio (HR [95% CI]) of newly diagnosed AAA was 1.30 [1.06-1.59] for BMI 25-<30 kg/m2 and 1.69 [1.24-2.30] for BMI ≥ 30 kg/m2. The risk of diagnosed AAA was significantly higher by 6% with each unit increase in baseline BMI. This association was consistent regardless of the other known AAA risk factors and preexisting vascular diseases. Overall, baseline history of diabetes tended to be associated with a lower risk of diagnosed AAA (HR = 0.79 [0.57-1.11]); this association appeared to vary by follow-up time (HR = 1.56 and 0.63 during ≤ and >2 years' follow-up, resp.). Conclusion. In a large cohort of middle-aged and older men, obesity was associated with a higher risk, while history of diabetes tended to associate with a lower risk of diagnosed AAA, particularly over longer follow-up.

Original languageEnglish (US)
Article number3521649
JournalJournal of Obesity
Volume2017
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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    Wang, L., Djousse, L., Song, Y., Akinkuolie, A. O., Matsumoto, C., Manson, J. E., Gaziano, J. M., & Sesso, H. D. (2017). Associations of Diabetes and Obesity with Risk of Abdominal Aortic Aneurysm in Men. Journal of Obesity, 2017, [3521649]. https://doi.org/10.1155/2017/3521649