Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families

Vivia V. Mccutcheon, Arpana Agrawal, Sally I.Chun Kuo, Jinni Su, Danielle M. Dick, Jacquelyn L. Meyers, Howard Edenberg, John Nurnberger, John R. Kramer, Samuel Kuperman, Marc A. Schuckit, Victor M. Hesselbrock, Andrew Brooks, Bernice Porjesz, Kathleen K. Bucholz

Research output: Contribution to journalArticle

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Abstract

Background and Aims: Parental alcohol use disorders (AUDs) and parental separation are associated with increased risk for early use of alcohol in offspring, but whether they increase risks for early use of other substances and for early sexual debut is under-studied. We focused on associations of parental AUDs and parental separation with substance initiation and sexual debut to (1) test the strength of the associations of parental AUDs and parental separation with time to initiation (age in years) of alcohol, tobacco and cannabis use and sexual debut and (2) compare the strength of association of parental AUD and parental separation with initiation. Design: Prospective adolescent and young adult cohort of a high-risk family study, the Collaborative Study on the Genetics of Alcoholism (COGA). Setting: Six sites in the United States. Participants: A total of 3257 offspring (aged 14-33 years) first assessed in 2004 and sought for interview approximately every 2 years thereafter; 1945 (59.7%) offspring had a parent with an AUD. Measurements: Diagnostic interview data on offspring substance use and sexual debut were based on first report of these experiences. Parental life-time AUD was based on their own self-report when parents were interviewed (1991-2005) for most parents, or on offspring and other family member reports for parents who were not interviewed. Parental separation was based on offspring reports of not living with both biological parents most of the time between ages 12 and 17 years. Findings: Parental AUDs were associated with increased hazards for all outcomes, with cumulative hazards ranging from 1.19 to 2.71. Parental separation was also an independent and consistent predictor of early substance use and sexual debut, with hazards ranging from 1.19 to 2.34. The strength of association of parental separation with substance initiation was equal to that of having two AUD-affected parents, and its association with sexual debut was stronger than the association of parental AUD in one or both parents. Conclusions: Parental alcohol use disorders (AUDs) and parental separation are independent and consistent predictors of increased risk for early alcohol, tobacco and cannabis use and sexual debut in offspring from families with a high risk of parental AUDs.

Original languageEnglish (US)
JournalAddiction
DOIs
StateAccepted/In press - 2017

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Cannabis
Tobacco Products
Alcohols
Parents
Tobacco Use
Interviews
Self Report
Alcoholism
Young Adult

Keywords

  • Alcohol use disorders
  • Cannabis
  • COGA
  • Early substance use
  • Familial
  • Parent AUD
  • Sexual debut
  • Tobacco

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families. / Mccutcheon, Vivia V.; Agrawal, Arpana; Kuo, Sally I.Chun; Su, Jinni; Dick, Danielle M.; Meyers, Jacquelyn L.; Edenberg, Howard; Nurnberger, John; Kramer, John R.; Kuperman, Samuel; Schuckit, Marc A.; Hesselbrock, Victor M.; Brooks, Andrew; Porjesz, Bernice; Bucholz, Kathleen K.

In: Addiction, 2017.

Research output: Contribution to journalArticle

Mccutcheon, VV, Agrawal, A, Kuo, SIC, Su, J, Dick, DM, Meyers, JL, Edenberg, H, Nurnberger, J, Kramer, JR, Kuperman, S, Schuckit, MA, Hesselbrock, VM, Brooks, A, Porjesz, B & Bucholz, KK 2017, 'Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families', Addiction. https://doi.org/10.1111/add.14003
Mccutcheon, Vivia V. ; Agrawal, Arpana ; Kuo, Sally I.Chun ; Su, Jinni ; Dick, Danielle M. ; Meyers, Jacquelyn L. ; Edenberg, Howard ; Nurnberger, John ; Kramer, John R. ; Kuperman, Samuel ; Schuckit, Marc A. ; Hesselbrock, Victor M. ; Brooks, Andrew ; Porjesz, Bernice ; Bucholz, Kathleen K. / Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families. In: Addiction. 2017.
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abstract = "Background and Aims: Parental alcohol use disorders (AUDs) and parental separation are associated with increased risk for early use of alcohol in offspring, but whether they increase risks for early use of other substances and for early sexual debut is under-studied. We focused on associations of parental AUDs and parental separation with substance initiation and sexual debut to (1) test the strength of the associations of parental AUDs and parental separation with time to initiation (age in years) of alcohol, tobacco and cannabis use and sexual debut and (2) compare the strength of association of parental AUD and parental separation with initiation. Design: Prospective adolescent and young adult cohort of a high-risk family study, the Collaborative Study on the Genetics of Alcoholism (COGA). Setting: Six sites in the United States. Participants: A total of 3257 offspring (aged 14-33 years) first assessed in 2004 and sought for interview approximately every 2 years thereafter; 1945 (59.7{\%}) offspring had a parent with an AUD. Measurements: Diagnostic interview data on offspring substance use and sexual debut were based on first report of these experiences. Parental life-time AUD was based on their own self-report when parents were interviewed (1991-2005) for most parents, or on offspring and other family member reports for parents who were not interviewed. Parental separation was based on offspring reports of not living with both biological parents most of the time between ages 12 and 17 years. Findings: Parental AUDs were associated with increased hazards for all outcomes, with cumulative hazards ranging from 1.19 to 2.71. Parental separation was also an independent and consistent predictor of early substance use and sexual debut, with hazards ranging from 1.19 to 2.34. The strength of association of parental separation with substance initiation was equal to that of having two AUD-affected parents, and its association with sexual debut was stronger than the association of parental AUD in one or both parents. Conclusions: Parental alcohol use disorders (AUDs) and parental separation are independent and consistent predictors of increased risk for early alcohol, tobacco and cannabis use and sexual debut in offspring from families with a high risk of parental AUDs.",
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author = "Mccutcheon, {Vivia V.} and Arpana Agrawal and Kuo, {Sally I.Chun} and Jinni Su and Dick, {Danielle M.} and Meyers, {Jacquelyn L.} and Howard Edenberg and John Nurnberger and Kramer, {John R.} and Samuel Kuperman and Schuckit, {Marc A.} and Hesselbrock, {Victor M.} and Andrew Brooks and Bernice Porjesz and Bucholz, {Kathleen K.}",
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T1 - Associations of parental alcohol use disorders and parental separation with offspring initiation of alcohol, cigarette and cannabis use and sexual debut in high-risk families

AU - Mccutcheon, Vivia V.

AU - Agrawal, Arpana

AU - Kuo, Sally I.Chun

AU - Su, Jinni

AU - Dick, Danielle M.

AU - Meyers, Jacquelyn L.

AU - Edenberg, Howard

AU - Nurnberger, John

AU - Kramer, John R.

AU - Kuperman, Samuel

AU - Schuckit, Marc A.

AU - Hesselbrock, Victor M.

AU - Brooks, Andrew

AU - Porjesz, Bernice

AU - Bucholz, Kathleen K.

PY - 2017

Y1 - 2017

N2 - Background and Aims: Parental alcohol use disorders (AUDs) and parental separation are associated with increased risk for early use of alcohol in offspring, but whether they increase risks for early use of other substances and for early sexual debut is under-studied. We focused on associations of parental AUDs and parental separation with substance initiation and sexual debut to (1) test the strength of the associations of parental AUDs and parental separation with time to initiation (age in years) of alcohol, tobacco and cannabis use and sexual debut and (2) compare the strength of association of parental AUD and parental separation with initiation. Design: Prospective adolescent and young adult cohort of a high-risk family study, the Collaborative Study on the Genetics of Alcoholism (COGA). Setting: Six sites in the United States. Participants: A total of 3257 offspring (aged 14-33 years) first assessed in 2004 and sought for interview approximately every 2 years thereafter; 1945 (59.7%) offspring had a parent with an AUD. Measurements: Diagnostic interview data on offspring substance use and sexual debut were based on first report of these experiences. Parental life-time AUD was based on their own self-report when parents were interviewed (1991-2005) for most parents, or on offspring and other family member reports for parents who were not interviewed. Parental separation was based on offspring reports of not living with both biological parents most of the time between ages 12 and 17 years. Findings: Parental AUDs were associated with increased hazards for all outcomes, with cumulative hazards ranging from 1.19 to 2.71. Parental separation was also an independent and consistent predictor of early substance use and sexual debut, with hazards ranging from 1.19 to 2.34. The strength of association of parental separation with substance initiation was equal to that of having two AUD-affected parents, and its association with sexual debut was stronger than the association of parental AUD in one or both parents. Conclusions: Parental alcohol use disorders (AUDs) and parental separation are independent and consistent predictors of increased risk for early alcohol, tobacco and cannabis use and sexual debut in offspring from families with a high risk of parental AUDs.

AB - Background and Aims: Parental alcohol use disorders (AUDs) and parental separation are associated with increased risk for early use of alcohol in offspring, but whether they increase risks for early use of other substances and for early sexual debut is under-studied. We focused on associations of parental AUDs and parental separation with substance initiation and sexual debut to (1) test the strength of the associations of parental AUDs and parental separation with time to initiation (age in years) of alcohol, tobacco and cannabis use and sexual debut and (2) compare the strength of association of parental AUD and parental separation with initiation. Design: Prospective adolescent and young adult cohort of a high-risk family study, the Collaborative Study on the Genetics of Alcoholism (COGA). Setting: Six sites in the United States. Participants: A total of 3257 offspring (aged 14-33 years) first assessed in 2004 and sought for interview approximately every 2 years thereafter; 1945 (59.7%) offspring had a parent with an AUD. Measurements: Diagnostic interview data on offspring substance use and sexual debut were based on first report of these experiences. Parental life-time AUD was based on their own self-report when parents were interviewed (1991-2005) for most parents, or on offspring and other family member reports for parents who were not interviewed. Parental separation was based on offspring reports of not living with both biological parents most of the time between ages 12 and 17 years. Findings: Parental AUDs were associated with increased hazards for all outcomes, with cumulative hazards ranging from 1.19 to 2.71. Parental separation was also an independent and consistent predictor of early substance use and sexual debut, with hazards ranging from 1.19 to 2.34. The strength of association of parental separation with substance initiation was equal to that of having two AUD-affected parents, and its association with sexual debut was stronger than the association of parental AUD in one or both parents. Conclusions: Parental alcohol use disorders (AUDs) and parental separation are independent and consistent predictors of increased risk for early alcohol, tobacco and cannabis use and sexual debut in offspring from families with a high risk of parental AUDs.

KW - Alcohol use disorders

KW - Cannabis

KW - COGA

KW - Early substance use

KW - Familial

KW - Parent AUD

KW - Sexual debut

KW - Tobacco

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