Astrocytic and synaptic response to kindling in hippocampal subfield CA1. I. Synaptogenesis in response to kindling in vitro

Fen Lei F. Chang, Nicholas Hawrylak, William T. Greenough

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Early morphological events associated with the genesis of epileptiform activity are essentially unknown, despite significant progress on morphological correlates of potentially related plastic neural phenomena. Hippocampal area CA1 shows the capacity to generate epileptiform bursting activity after certain patterns of electrical stimulation. Using an in vitro slice kindling preparation, we found increases in the numbers (areal densities) of shaft and sessile spine synapses in hippocampal subfield CA1 within minutes following the establishment of stable afterdischarges. These data strongly suggest that synaptogenesis is associated with the early stages of epilepsy formation.

Original languageEnglish (US)
Pages (from-to)302-308
Number of pages7
JournalBrain research
Volume603
Issue number2
DOIs
StatePublished - Feb 19 1993
Externally publishedYes

Keywords

  • Brain slice
  • Epilepsy
  • Hippocampal subfield CA1
  • Kindling
  • Spine synapse
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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