At-home short daily hemodialysis improves the long-term health-related quality of life

Fredric O. Finkelstein, Brigitte Schiller, Rachid Daoui, Todd W. Gehr, Michael Kraus, Janice Lea, Yoojin Lee, Brent W. Miller, Marvin Sinsakul, Bertrand L. Jaber

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Patients with chronic kidney disease treated by in-center conventional hemodialysis (3 times per week) have significant impairments in health-related quality of life measures, which have been associated with increased morbidity and mortality. FREEDOM is an ongoing prospective cohort study measuring the potential benefits of at-home short daily (6 times per week) hemodialysis. In this interim report we examine the long-term effect of short daily hemodialysis on health-related quality of life, as measured by the SF-36 health survey. This was administered at baseline, 4 and 12 months after initiation of short daily hemodialysis to 291 participants (total cohort), of which 154 completed the 12-month follow-up (as-treated cohort). At the time of analysis, the mean age was 53 years, 66% were men, 58% had an AV fistula, 90% transitioned from in-center hemodialysis, and 45% had diabetes mellitus. In the total cohort analysis, both the physical- and mental-component summary scores improved over the 12-month period, as did all 8 individual domains of the SF-36. The as-treated cohort analysis showed similar improvements with the exception of the role-emotional domain. Significantly, in the as-treated cohort, the percentage of patients achieving a physical-component summary score at least equivalent to the general population more than doubled. Hence, at-home short daily hemodialysis is associated with long-term improvements in various physical and mental health-related quality of life measures.

Original languageEnglish
Pages (from-to)561-569
Number of pages9
JournalKidney International
Volume82
Issue number5
DOIs
StatePublished - Sep 1 2012

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Renal Dialysis
Quality of Life
Cohort Studies
Health Surveys
Chronic Renal Insufficiency
Fistula
Diabetes Mellitus
Mental Health
Prospective Studies
Morbidity
Mortality
Population

Keywords

  • home hemodialysis
  • HRQOL
  • SF-36
  • short daily hemodialysis

ASJC Scopus subject areas

  • Nephrology

Cite this

Finkelstein, F. O., Schiller, B., Daoui, R., Gehr, T. W., Kraus, M., Lea, J., ... Jaber, B. L. (2012). At-home short daily hemodialysis improves the long-term health-related quality of life. Kidney International, 82(5), 561-569. https://doi.org/10.1038/ki.2012.168

At-home short daily hemodialysis improves the long-term health-related quality of life. / Finkelstein, Fredric O.; Schiller, Brigitte; Daoui, Rachid; Gehr, Todd W.; Kraus, Michael; Lea, Janice; Lee, Yoojin; Miller, Brent W.; Sinsakul, Marvin; Jaber, Bertrand L.

In: Kidney International, Vol. 82, No. 5, 01.09.2012, p. 561-569.

Research output: Contribution to journalArticle

Finkelstein, FO, Schiller, B, Daoui, R, Gehr, TW, Kraus, M, Lea, J, Lee, Y, Miller, BW, Sinsakul, M & Jaber, BL 2012, 'At-home short daily hemodialysis improves the long-term health-related quality of life', Kidney International, vol. 82, no. 5, pp. 561-569. https://doi.org/10.1038/ki.2012.168
Finkelstein FO, Schiller B, Daoui R, Gehr TW, Kraus M, Lea J et al. At-home short daily hemodialysis improves the long-term health-related quality of life. Kidney International. 2012 Sep 1;82(5):561-569. https://doi.org/10.1038/ki.2012.168
Finkelstein, Fredric O. ; Schiller, Brigitte ; Daoui, Rachid ; Gehr, Todd W. ; Kraus, Michael ; Lea, Janice ; Lee, Yoojin ; Miller, Brent W. ; Sinsakul, Marvin ; Jaber, Bertrand L. / At-home short daily hemodialysis improves the long-term health-related quality of life. In: Kidney International. 2012 ; Vol. 82, No. 5. pp. 561-569.
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