At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone

John Foley, Nicole Nickerson, David J. Riese, Peter Hollenhorst, Gwendolen Lorch, Anne M. Foley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.

Original languageEnglish
Pages (from-to)109-129
Number of pages21
JournalOdontology
Volume100
Issue number2
DOIs
StatePublished - Jul 2012

Fingerprint

Parathyroid Hormone-Related Protein
Bone Diseases
Epidermal Growth Factor Receptor
Neoplasm Metastasis
Bone Neoplasms
Neoplasms
Hypercalcemia
Apoptosis
Growth
Therapeutics

Keywords

  • Bone metastasis
  • EGFR
  • Gene expression
  • Hypercalcemia
  • PTHrP
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

At the crossroads : EGFR and PTHrP signaling in cancer-mediated diseases of bone. / Foley, John; Nickerson, Nicole; Riese, David J.; Hollenhorst, Peter; Lorch, Gwendolen; Foley, Anne M.

In: Odontology, Vol. 100, No. 2, 07.2012, p. 109-129.

Research output: Contribution to journalArticle

Foley, John ; Nickerson, Nicole ; Riese, David J. ; Hollenhorst, Peter ; Lorch, Gwendolen ; Foley, Anne M. / At the crossroads : EGFR and PTHrP signaling in cancer-mediated diseases of bone. In: Odontology. 2012 ; Vol. 100, No. 2. pp. 109-129.
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