At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone

John Foley, Nicole Nickerson, David J. Riese, Peter C. Hollenhorst, Gwendolen Lorch, Anne M. Foley

Research output: Contribution to journalReview article

10 Scopus citations


The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.

Original languageEnglish (US)
Pages (from-to)109-129
Number of pages21
Issue number2
StatePublished - Jul 1 2012


  • Bone metastasis
  • EGFR
  • Gene expression
  • Hypercalcemia
  • PTHrP
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Dentistry(all)

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