Atomoxetine treatment of ADHD in children with comorbid tourette syndrome

Thomas J. Spencer, F. Randy Sallee, Donald L. Gilbert, David Dunn, James T. McCracken, Barbara J. Coffey, Cathy L. Budman, Randall K. Ricardi, Henrietta L. Leonard, Albert J. Allen, Denai R. Milton, Peter D. Feldman, Douglas K. Kelsey, Daniel A. Geller, Steven L. Linder, Donald W. Lewis, Paul K. Winner, Roger M. Kurlan, Mark Mintz

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objective: This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS). Method: Subjects (7-17 years old) with ADHD (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV) and TS were randomly assigned to double-blind treatment with placebo (n = 56) or atomoxetine (0.5-1.5 mg/kg/day, n = 61) for approximately 18 weeks. Results: Atomoxetine subjects showed significantly greater improvement on ADHD symptom measures. Treatment was also associated with significantly greater reduction of tic severity on two of three measures. Significant increases were seen in mean pulse rate and rates of treatment-emergent nausea, decreased appetite, and decreased body weight. No other clinically relevant treatment differences were observed in any other vital sign, adverse event, laboratory parameter, or electrocardiographic measure. Conclusion: Atomoxetine is efficacious for treatment of ADHD and its use appears well tolerated in ADHD patients with comorbid TS. (J. of Att. Dis. 2008; 11(4) 470-481).

Original languageEnglish
Pages (from-to)470-481
Number of pages12
JournalJournal of Attention Disorders
Volume11
Issue number4
DOIs
StatePublished - Jan 2008

Fingerprint

Tourette Syndrome
Tics
Diagnostic and Statistical Manual of Mental Disorders
Therapeutics
Vital Signs
Appetite
Nausea
Atomoxetine Hydrochloride
Heart Rate
Placebos
Body Weight

Keywords

  • ADHD
  • Atomoxetine
  • Tic disorders
  • Tourette syndrome

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Spencer, T. J., Sallee, F. R., Gilbert, D. L., Dunn, D., McCracken, J. T., Coffey, B. J., ... Mintz, M. (2008). Atomoxetine treatment of ADHD in children with comorbid tourette syndrome. Journal of Attention Disorders, 11(4), 470-481. https://doi.org/10.1177/1087054707306109

Atomoxetine treatment of ADHD in children with comorbid tourette syndrome. / Spencer, Thomas J.; Sallee, F. Randy; Gilbert, Donald L.; Dunn, David; McCracken, James T.; Coffey, Barbara J.; Budman, Cathy L.; Ricardi, Randall K.; Leonard, Henrietta L.; Allen, Albert J.; Milton, Denai R.; Feldman, Peter D.; Kelsey, Douglas K.; Geller, Daniel A.; Linder, Steven L.; Lewis, Donald W.; Winner, Paul K.; Kurlan, Roger M.; Mintz, Mark.

In: Journal of Attention Disorders, Vol. 11, No. 4, 01.2008, p. 470-481.

Research output: Contribution to journalArticle

Spencer, TJ, Sallee, FR, Gilbert, DL, Dunn, D, McCracken, JT, Coffey, BJ, Budman, CL, Ricardi, RK, Leonard, HL, Allen, AJ, Milton, DR, Feldman, PD, Kelsey, DK, Geller, DA, Linder, SL, Lewis, DW, Winner, PK, Kurlan, RM & Mintz, M 2008, 'Atomoxetine treatment of ADHD in children with comorbid tourette syndrome', Journal of Attention Disorders, vol. 11, no. 4, pp. 470-481. https://doi.org/10.1177/1087054707306109
Spencer, Thomas J. ; Sallee, F. Randy ; Gilbert, Donald L. ; Dunn, David ; McCracken, James T. ; Coffey, Barbara J. ; Budman, Cathy L. ; Ricardi, Randall K. ; Leonard, Henrietta L. ; Allen, Albert J. ; Milton, Denai R. ; Feldman, Peter D. ; Kelsey, Douglas K. ; Geller, Daniel A. ; Linder, Steven L. ; Lewis, Donald W. ; Winner, Paul K. ; Kurlan, Roger M. ; Mintz, Mark. / Atomoxetine treatment of ADHD in children with comorbid tourette syndrome. In: Journal of Attention Disorders. 2008 ; Vol. 11, No. 4. pp. 470-481.
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