Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness

Edgar E. Sarria, Rita Mattiello, Weiguo Yao, Valentina Chakr, Christina J. Tiller, Jeffrey Kisling, Rebeka Tabbey, Zhangsheng Yu, Mark Kaplan, Robert Tepper

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Childhood asthma is often characterized by recurrent wheezing, airway hyper-reactivity, atopy, and altered immune characteristics; however, our understanding of the development of these relationships from early in life remains unclear. The aim of our study was to evaluate whether atopy, cytokine production by peripheral blood mononuclear cells (PBMCs), and airway responsiveness, assessed in infants and toddlers, are associated with asthma and airway responsiveness at 4-years of age. Methods Infants with eczema (N = 116), enrolled prior to wheezing, were assessed at entry (mean age of 10.7 months), at 1-year follow-up (N = 112), and at 4-years of age (N = 94). Total serum IgE, specific IgE to allergens, and cytokines produced by stimulated PBMCs, were assessed at entry and 1-year follow-up. Spirometry was obtained at all 3-visits, while airway reactivity to methacholine was assessed at entry and 1-year follow-up, and bronchodilator (BD) responsiveness, as well as current asthma was assessed at 4-years of age. Results We found that pre-school children with asthma had lower spirometry and a greater BD-response. Serum IgE, particularly to egg and/or milk, and altered cytokine production by PBMCs at entry to the study were associated with asthma, lower spirometry, and greater airway responsiveness at 4-years of age. In addition, we found that airway responsiveness, as well as spirometry, tracked from infancy to 4-years of age. Conclusions While spirometry and airway responsiveness track longitudinally from early in life, atopy and cytokine production by PBMCs are associated not only with an increased risk of pre-school asthma, but also lower spirometry and increased airway responsiveness. Pediatr Pulmonol. 2014; 49:132-139.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalPediatric Pulmonology
Volume49
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

Spirometry
Asthma
Cytokines
Blood Cells
Immunoglobulin E
Bronchodilator Agents
Respiratory Sounds
Methacholine Chloride
Eczema
Serum
Allergens
Ovum
Milk

Keywords

  • airway reactivity
  • bronchodilator response
  • infants
  • pre-school children
  • spirometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness. / Sarria, Edgar E.; Mattiello, Rita; Yao, Weiguo; Chakr, Valentina; Tiller, Christina J.; Kisling, Jeffrey; Tabbey, Rebeka; Yu, Zhangsheng; Kaplan, Mark; Tepper, Robert.

In: Pediatric Pulmonology, Vol. 49, No. 2, 02.2014, p. 132-139.

Research output: Contribution to journalArticle

Sarria, Edgar E. ; Mattiello, Rita ; Yao, Weiguo ; Chakr, Valentina ; Tiller, Christina J. ; Kisling, Jeffrey ; Tabbey, Rebeka ; Yu, Zhangsheng ; Kaplan, Mark ; Tepper, Robert. / Atopy, cytokine production, and airway reactivity as predictors of pre-school asthma and airway responsiveness. In: Pediatric Pulmonology. 2014 ; Vol. 49, No. 2. pp. 132-139.
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AU - Mattiello, Rita

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AU - Tiller, Christina J.

AU - Kisling, Jeffrey

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AU - Yu, Zhangsheng

AU - Kaplan, Mark

AU - Tepper, Robert

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AB - Background Childhood asthma is often characterized by recurrent wheezing, airway hyper-reactivity, atopy, and altered immune characteristics; however, our understanding of the development of these relationships from early in life remains unclear. The aim of our study was to evaluate whether atopy, cytokine production by peripheral blood mononuclear cells (PBMCs), and airway responsiveness, assessed in infants and toddlers, are associated with asthma and airway responsiveness at 4-years of age. Methods Infants with eczema (N = 116), enrolled prior to wheezing, were assessed at entry (mean age of 10.7 months), at 1-year follow-up (N = 112), and at 4-years of age (N = 94). Total serum IgE, specific IgE to allergens, and cytokines produced by stimulated PBMCs, were assessed at entry and 1-year follow-up. Spirometry was obtained at all 3-visits, while airway reactivity to methacholine was assessed at entry and 1-year follow-up, and bronchodilator (BD) responsiveness, as well as current asthma was assessed at 4-years of age. Results We found that pre-school children with asthma had lower spirometry and a greater BD-response. Serum IgE, particularly to egg and/or milk, and altered cytokine production by PBMCs at entry to the study were associated with asthma, lower spirometry, and greater airway responsiveness at 4-years of age. In addition, we found that airway responsiveness, as well as spirometry, tracked from infancy to 4-years of age. Conclusions While spirometry and airway responsiveness track longitudinally from early in life, atopy and cytokine production by PBMCs are associated not only with an increased risk of pre-school asthma, but also lower spirometry and increased airway responsiveness. Pediatr Pulmonol. 2014; 49:132-139.

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