Atrial natriuretic factor and transgenic mice

Gou Young Koh, Michael G. Klug, Loren J. Field

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Atrial natriuretic factor (ANF) is a peptide hormone that induces potent but transient hypotensive and natriuretic responses on short-term administration. The role of the hormone in long-term cardiovascular regulation has remained elusive in part because of the temporal limitations of long-term infusion models and the extremely short half-life of the molecule in vivo. To circumvent these temporal limitations, a transgenic mouse model was developed that exhibits lifelong elevated plasma ANF levels. These mice are chronically hypotensive, with arterial pressures averaging 20 to 30 mm Hg less than those observed in nontransgenic siblings. In contrast, no obvious natriuretic or diuretic phenotype was observed in transgenic animals housed in metabolic cages. Thus, the mice adequately compensate for the renal effects but not the hemodynamic effects of the hormone. The ANF transgenic mice provide a tractable model system with which to study the consequences of long-term alterations of ANF expression in vivo.

Original languageEnglish (US)
Pages (from-to)634-639
Number of pages6
JournalHypertension
Volume22
Issue number4
DOIs
StatePublished - Oct 1993

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Keywords

  • Atrial natriuretic factor
  • Mice, transgenic

ASJC Scopus subject areas

  • Internal Medicine

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