Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

Research output: Contribution to journalArticle

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Abstract

Transgenic mice that carry fusions between the transcriptional regulatory sequences of atrial natriuretic factor (a hormone intimately involved in the regulation of blood pressure) and those encoding SV40 T antigen (an oncoprotein) were generated. Although both atria express the fusion gene, the pathological response to T antigen is asymmetrical. The right atrium undergoes a several hundredfold increase in mass while the left atrium remains relatively normal in size. Hyperplasia is accompanied by a progressive increase in both the frequency and severity of abnormalities in the atrial conduction system, which ultimately result in death.

Original languageEnglish (US)
Pages (from-to)1029-1033
Number of pages5
JournalScience
Volume239
Issue number4843
StatePublished - 1988
Externally publishedYes

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Polyomavirus Transforming Antigens
Atrial Natriuretic Factor
Heart Atria
Transgenes
Cardiac Arrhythmias
Gene Fusion
Oncogene Proteins
Viral Tumor Antigens
Transgenic Mice
Hyperplasia
Neoplasms
Hormones
Blood Pressure

ASJC Scopus subject areas

  • General

Cite this

Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice. / Field, Loren.

In: Science, Vol. 239, No. 4843, 1988, p. 1029-1033.

Research output: Contribution to journalArticle

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