Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium

Role of the obstacle size

Takanori Ikeda, Masaaki Yashima, Takumi Uchida, Dustan Hough, Michael C. Fishbein, William J. Mandel, Peng-Sheng Chen, Hrayr S. Karagueuzian

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Acetylcholine chloride (ACh) induces nonstationary meandering reentrant wave fronts in the atrium. We hypothesized that an anatomic obstacle of a suitable size prevents meandering by causing attachment of the reentrant wave front tip to the obstacle. Eight isolated canine right atrial tissues (area, 3.8x3.2 cm) were mounted in a tissue bath and superfused with Tyrode's solution containing 10 to 15 μmol/L ACh. Holes with 2- to 10-mm diameters were sequentially created in the center of the tissue with biopsy punches. Reentry was induced by a premature stimulus after eight regular stimuli at 400-ms cycle length. The endocardial activation maps and the motion of the induced reentry were visualized dynamically before and after each test lesion using 509 bipolar electrodes. In the absence of a lesion (n=8), the induced single reentrant wave front, in the form of a spiral wave, meandered irregularly from one site to another before terminating at the tissue border. Holes with 2- to 4-mm diameters (n=6) had no effect on meandering. However, when the hole diameters were increased to 6 mm (n=8), 8 mm (n=8), and 10 mm (n=6), the tip of the spiral wave attached to the holes, and reentry became stationary. Transition from meandering to an attached state converted the irregular and polymorphic electrogram to a periodic and monomorphic activity with longer cycle lengths (101±11 versus 131±9 ms for no hole versus 10-mm hole, respectively; P

Original languageEnglish (US)
Pages (from-to)753-764
Number of pages12
JournalCirculation Research
Volume81
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Acetylcholine
Baths
Canidae
Electrodes
Biopsy
Tyrode's solution

Keywords

  • Acetylcholine
  • Atrium
  • Mapping
  • Reentry
  • Source-sink relationship

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Ikeda, T., Yashima, M., Uchida, T., Hough, D., Fishbein, M. C., Mandel, W. J., ... Karagueuzian, H. S. (1997). Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium: Role of the obstacle size. Circulation Research, 81(5), 753-764.

Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium : Role of the obstacle size. / Ikeda, Takanori; Yashima, Masaaki; Uchida, Takumi; Hough, Dustan; Fishbein, Michael C.; Mandel, William J.; Chen, Peng-Sheng; Karagueuzian, Hrayr S.

In: Circulation Research, Vol. 81, No. 5, 1997, p. 753-764.

Research output: Contribution to journalArticle

Ikeda, T, Yashima, M, Uchida, T, Hough, D, Fishbein, MC, Mandel, WJ, Chen, P-S & Karagueuzian, HS 1997, 'Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium: Role of the obstacle size', Circulation Research, vol. 81, no. 5, pp. 753-764.
Ikeda T, Yashima M, Uchida T, Hough D, Fishbein MC, Mandel WJ et al. Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium: Role of the obstacle size. Circulation Research. 1997;81(5):753-764.
Ikeda, Takanori ; Yashima, Masaaki ; Uchida, Takumi ; Hough, Dustan ; Fishbein, Michael C. ; Mandel, William J. ; Chen, Peng-Sheng ; Karagueuzian, Hrayr S. / Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium : Role of the obstacle size. In: Circulation Research. 1997 ; Vol. 81, No. 5. pp. 753-764.
@article{b792400e18124fff8a0caa0adac70f20,
title = "Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium: Role of the obstacle size",
abstract = "Acetylcholine chloride (ACh) induces nonstationary meandering reentrant wave fronts in the atrium. We hypothesized that an anatomic obstacle of a suitable size prevents meandering by causing attachment of the reentrant wave front tip to the obstacle. Eight isolated canine right atrial tissues (area, 3.8x3.2 cm) were mounted in a tissue bath and superfused with Tyrode's solution containing 10 to 15 μmol/L ACh. Holes with 2- to 10-mm diameters were sequentially created in the center of the tissue with biopsy punches. Reentry was induced by a premature stimulus after eight regular stimuli at 400-ms cycle length. The endocardial activation maps and the motion of the induced reentry were visualized dynamically before and after each test lesion using 509 bipolar electrodes. In the absence of a lesion (n=8), the induced single reentrant wave front, in the form of a spiral wave, meandered irregularly from one site to another before terminating at the tissue border. Holes with 2- to 4-mm diameters (n=6) had no effect on meandering. However, when the hole diameters were increased to 6 mm (n=8), 8 mm (n=8), and 10 mm (n=6), the tip of the spiral wave attached to the holes, and reentry became stationary. Transition from meandering to an attached state converted the irregular and polymorphic electrogram to a periodic and monomorphic activity with longer cycle lengths (101±11 versus 131±9 ms for no hole versus 10-mm hole, respectively; P",
keywords = "Acetylcholine, Atrium, Mapping, Reentry, Source-sink relationship",
author = "Takanori Ikeda and Masaaki Yashima and Takumi Uchida and Dustan Hough and Fishbein, {Michael C.} and Mandel, {William J.} and Peng-Sheng Chen and Karagueuzian, {Hrayr S.}",
year = "1997",
language = "English (US)",
volume = "81",
pages = "753--764",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium

T2 - Role of the obstacle size

AU - Ikeda, Takanori

AU - Yashima, Masaaki

AU - Uchida, Takumi

AU - Hough, Dustan

AU - Fishbein, Michael C.

AU - Mandel, William J.

AU - Chen, Peng-Sheng

AU - Karagueuzian, Hrayr S.

PY - 1997

Y1 - 1997

N2 - Acetylcholine chloride (ACh) induces nonstationary meandering reentrant wave fronts in the atrium. We hypothesized that an anatomic obstacle of a suitable size prevents meandering by causing attachment of the reentrant wave front tip to the obstacle. Eight isolated canine right atrial tissues (area, 3.8x3.2 cm) were mounted in a tissue bath and superfused with Tyrode's solution containing 10 to 15 μmol/L ACh. Holes with 2- to 10-mm diameters were sequentially created in the center of the tissue with biopsy punches. Reentry was induced by a premature stimulus after eight regular stimuli at 400-ms cycle length. The endocardial activation maps and the motion of the induced reentry were visualized dynamically before and after each test lesion using 509 bipolar electrodes. In the absence of a lesion (n=8), the induced single reentrant wave front, in the form of a spiral wave, meandered irregularly from one site to another before terminating at the tissue border. Holes with 2- to 4-mm diameters (n=6) had no effect on meandering. However, when the hole diameters were increased to 6 mm (n=8), 8 mm (n=8), and 10 mm (n=6), the tip of the spiral wave attached to the holes, and reentry became stationary. Transition from meandering to an attached state converted the irregular and polymorphic electrogram to a periodic and monomorphic activity with longer cycle lengths (101±11 versus 131±9 ms for no hole versus 10-mm hole, respectively; P

AB - Acetylcholine chloride (ACh) induces nonstationary meandering reentrant wave fronts in the atrium. We hypothesized that an anatomic obstacle of a suitable size prevents meandering by causing attachment of the reentrant wave front tip to the obstacle. Eight isolated canine right atrial tissues (area, 3.8x3.2 cm) were mounted in a tissue bath and superfused with Tyrode's solution containing 10 to 15 μmol/L ACh. Holes with 2- to 10-mm diameters were sequentially created in the center of the tissue with biopsy punches. Reentry was induced by a premature stimulus after eight regular stimuli at 400-ms cycle length. The endocardial activation maps and the motion of the induced reentry were visualized dynamically before and after each test lesion using 509 bipolar electrodes. In the absence of a lesion (n=8), the induced single reentrant wave front, in the form of a spiral wave, meandered irregularly from one site to another before terminating at the tissue border. Holes with 2- to 4-mm diameters (n=6) had no effect on meandering. However, when the hole diameters were increased to 6 mm (n=8), 8 mm (n=8), and 10 mm (n=6), the tip of the spiral wave attached to the holes, and reentry became stationary. Transition from meandering to an attached state converted the irregular and polymorphic electrogram to a periodic and monomorphic activity with longer cycle lengths (101±11 versus 131±9 ms for no hole versus 10-mm hole, respectively; P

KW - Acetylcholine

KW - Atrium

KW - Mapping

KW - Reentry

KW - Source-sink relationship

UR - http://www.scopus.com/inward/record.url?scp=0030698419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030698419&partnerID=8YFLogxK

M3 - Article

VL - 81

SP - 753

EP - 764

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 5

ER -