Attenuated total internal reflection Fourier transform infrared spectroscopy

A quantitative approach for kidney stone analysis

Heather J. Gulley-Stahl, Jennifer A. Haas, Katherine A. Schmidt, Andrew Evan, André J. Sommer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The impact of kidney stone disease is significant worldwide, yet methods for quantifying stone components remain limited. A new approach requiring minimal sample preparation for the quantitative analysis of kidney stone components has been investigated utilizing attenuated total internal reflection Fourier transform infrared spectroscopy (ATR-FT-IR). Calcium oxalate monohydrate (COM) and hydroxylapatite (HAP), two of the most common constituents of urinary stones, were used for quantitative analysis. Calibration curves were constructed using integrated band intensities of four infrared absorptions versus concentration (weight %). The correlation coefficients of the calibration curves range from 0.997 to 0.93. The limits of detection range from 0.07 ± 0.02% COM/HAP where COM is the analyte and HAP is the matrix, to 0.26 ± 0.07% HAP/COM where HAP is the analyte and COM is the matrix. This study shows that linear calibration curves can be generated for the quantitative analysis of stone mixtures provided the system is well understood especially with respect to particle size.

Original languageEnglish
Pages (from-to)759-766
Number of pages8
JournalApplied Spectroscopy
Volume63
Issue number7
DOIs
StatePublished - Jul 2009

Fingerprint

kidney stones
Calcium Oxalate
oxalates
Durapatite
Fourier transform infrared spectroscopy
calcium
Calcium
infrared spectroscopy
quantitative analysis
Calibration
rocks
curves
Chemical analysis
Infrared absorption
matrices
correlation coefficients
infrared absorption
Particle size
preparation

Keywords

  • Attenuated total reflection
  • Calcium oxalate monohydrate
  • Fourier transform infrared spectroscopy
  • Hydroxylapatite
  • Kidney stones
  • Quantitative ATR-FT-IR

ASJC Scopus subject areas

  • Spectroscopy
  • Instrumentation

Cite this

Attenuated total internal reflection Fourier transform infrared spectroscopy : A quantitative approach for kidney stone analysis. / Gulley-Stahl, Heather J.; Haas, Jennifer A.; Schmidt, Katherine A.; Evan, Andrew; Sommer, André J.

In: Applied Spectroscopy, Vol. 63, No. 7, 07.2009, p. 759-766.

Research output: Contribution to journalArticle

Gulley-Stahl, Heather J. ; Haas, Jennifer A. ; Schmidt, Katherine A. ; Evan, Andrew ; Sommer, André J. / Attenuated total internal reflection Fourier transform infrared spectroscopy : A quantitative approach for kidney stone analysis. In: Applied Spectroscopy. 2009 ; Vol. 63, No. 7. pp. 759-766.
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