Attenuation in the progression of cognitive deterioration in alzheimer's disease with rivastigmine: A dose-dependent effect

Martin Farlow, John Messina, Ravi Anand, Richard Hartman, Jeffrey Veach

Research output: Contribution to journalArticle

Abstract

Objectives: Possible disease-modifying effects ofrivastigmine have been suggested by analyses using a variation of the randomized start design; however, the results were someichat confounded by differing attrition rales. We report on an alternative method investigating whether increasing doses reduce the rates of cognitive decline in patients who continue treatment. Methods: The effect of dose on the rate of cognitive decline seen on the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADASCog) u'as explored for patients in a long-term (130-iceek) extension of a 26-iceek placebo-controlled trial using two methods: a weighted least squares regression analysis using each individual's slope, and a weighted analysis of variance (ANOVA) comparing the slopes of patients categorized by dose (<6 mg/d or >6 mg/d). Results: The results from 408 patients included in the weighted least squares analysis estimated the rate of decline to attenuate by approximately 1 point/yfor every 3 mg/d increase (P<.0001). The average annual rate of decline for patients whose mean dose was >6 mg/d w-as 4.5 points (95% Cl, 5.1-3.9), while for patients with a mean dose of>6 mg/d a decline of 8.2 points (95% Cl, 9.1-7.3) was seen. Conclusion: These data further support earlier results suggesting that rivastigmine reduces the rate of progression of cognitive deterioration in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)21-22
Number of pages2
JournalCNS Spectrums
Volume5
Issue number6
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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