Attenuation of pharmacological effects and increased metabolism of phencyclidine in morphine tolerant mice

Toshitaka Nabeshima, Subbiah Sivam, Ing K. Ho

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mice were used for a study of the interaction between morphine and phencyclidine (PCP) in relation to lethality, motor incoordination, locomotor activity and rearing, together with the half-life of PCP, following continuous administration of morphine by pellet (75 mg base) implantation for 72 h and after removal of the pellets for 6 and 24 h. PCP induced motor incoordination and suppressed locomotor activity and rearing; these effects were enhanced in morphine 'pellet-implanted' mice and were attenuated in morphine 'pellet-removed' groups. The enhancing effect of morphine on the PCP responses was attributable more to the presence of residual morphine than to the alterations in its disposition. The morphine-induced increase in locomotor activity and analgesia was attenuated in PCP (40 mg/kg per day i.p. for 5 days) tolerant mice. The rate of decay of PCP in serum and brain or morphine pellet-implanted animals was not different; however, in the 24 h 'pellet-removed' group, the rate of decay of PCP was increased. The results indicate that there is a two-way cross-tolerance development between PCP and morphine. The phenomenon appears to involve both dispositional and functional adaptation mechanisms.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalEuropean Journal of Pharmacology
Volume104
Issue number3-4
DOIs
StatePublished - Sep 17 1984
Externally publishedYes

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Phencyclidine
Morphine
Pharmacology
Locomotion
Ataxia
Analgesia
Half-Life

Keywords

  • Disposition
  • Interaction
  • Morphine
  • Phencyclidine (PCP)
  • Tolerance

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Attenuation of pharmacological effects and increased metabolism of phencyclidine in morphine tolerant mice. / Nabeshima, Toshitaka; Sivam, Subbiah; Ho, Ing K.

In: European Journal of Pharmacology, Vol. 104, No. 3-4, 17.09.1984, p. 211-221.

Research output: Contribution to journalArticle

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