Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion

Liang Cheng, Darrell D. Davidson, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi, Mingsheng Wang, Puay Hoon Tan, Lee Ann Baldridge, Shaobo Zhang

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Atypical adenomatous hyperplasia (AAH) is a distinct entity in prostate pathology, defined as a well-circumscribed lobule of closely packed crowded small glands or acini. Although it has been proposed as a precursor lesion to prostate cancer, the biological nature of AAH is currently uncertain. The TMPRSS2- ERG fusion gene is a common recurrent chromosomal rearrangement in prostate cancer and in its precursor lesion, prostatic intraepithelial neoplasia. The prevalence of TMPRSS2-ERG alteration in AAH is unknown. Fifty-five separate prostate specimens containing AAH were investigated by fluorescence in situ hybridization and immunohistochemistry for TMPRSS2-ERG rearrangement. TMPRSS2-ERG rearrangements were not identified in AAH either by fluorescence in situ hybridization or by immunohistochemistry.

Original languageEnglish (US)
Pages (from-to)1550-1554
Number of pages5
JournalAmerican Journal of Surgical Pathology
Issue number10
StatePublished - Oct 1 2013


  • Atypical adenomatous hyperplasia (adenosis)
  • Biomarkers
  • Cancer mimicker
  • Differential diagnosis
  • Prostate
  • TMPRSS2-ERG rearrangements

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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