Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion

Liang Cheng, Darrell Davidson, Gregory T. MacLennan, Antonio Lopez-Beltran, Rodolfo Montironi, Mingsheng Wang, Puay Hoon Tan, Lee Ann Baldridge, Shaobo Zhang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Atypical adenomatous hyperplasia (AAH) is a distinct entity in prostate pathology, defined as a well-circumscribed lobule of closely packed crowded small glands or acini. Although it has been proposed as a precursor lesion to prostate cancer, the biological nature of AAH is currently uncertain. The TMPRSS2- ERG fusion gene is a common recurrent chromosomal rearrangement in prostate cancer and in its precursor lesion, prostatic intraepithelial neoplasia. The prevalence of TMPRSS2-ERG alteration in AAH is unknown. Fifty-five separate prostate specimens containing AAH were investigated by fluorescence in situ hybridization and immunohistochemistry for TMPRSS2-ERG rearrangement. TMPRSS2-ERG rearrangements were not identified in AAH either by fluorescence in situ hybridization or by immunohistochemistry.

Original languageEnglish
Pages (from-to)1550-1554
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume37
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Gene Fusion
Hyperplasia
Prostate
Fluorescence In Situ Hybridization
Prostatic Neoplasms
Immunohistochemistry
Prostatic Intraepithelial Neoplasia
Pathology

Keywords

  • Atypical adenomatous hyperplasia (adenosis)
  • Biomarkers
  • Cancer mimicker
  • Differential diagnosis
  • Prostate
  • TMPRSS2-ERG rearrangements

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion. / Cheng, Liang; Davidson, Darrell; MacLennan, Gregory T.; Lopez-Beltran, Antonio; Montironi, Rodolfo; Wang, Mingsheng; Tan, Puay Hoon; Baldridge, Lee Ann; Zhang, Shaobo.

In: American Journal of Surgical Pathology, Vol. 37, No. 10, 10.2013, p. 1550-1554.

Research output: Contribution to journalArticle

Cheng, L, Davidson, D, MacLennan, GT, Lopez-Beltran, A, Montironi, R, Wang, M, Tan, PH, Baldridge, LA & Zhang, S 2013, 'Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion', American Journal of Surgical Pathology, vol. 37, no. 10, pp. 1550-1554. https://doi.org/10.1097/PAS.0b013e318294e9bc
Cheng, Liang ; Davidson, Darrell ; MacLennan, Gregory T. ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Wang, Mingsheng ; Tan, Puay Hoon ; Baldridge, Lee Ann ; Zhang, Shaobo. / Atypical adenomatous hyperplasia of prostate lacks TMPRSS2-ERG gene fusion. In: American Journal of Surgical Pathology. 2013 ; Vol. 37, No. 10. pp. 1550-1554.
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