Atypical adenomatous hyperplasia of the prostate: A premalignant lesion?

Liang Cheng, Ailin Shan, John C. Cheville, Junqi Qian, David G. Bostwick

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.

Original languageEnglish (US)
Pages (from-to)389-391
Number of pages3
JournalCancer Research
Volume58
Issue number3
StatePublished - Feb 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cheng, L., Shan, A., Cheville, J. C., Qian, J., & Bostwick, D. G. (1998). Atypical adenomatous hyperplasia of the prostate: A premalignant lesion? Cancer Research, 58(3), 389-391.