Atypical adenomatous hyperplasia of the prostate

A premalignant lesion?

Liang Cheng, Ailin Shan, John C. Cheville, Junqi Qian, David G. Bostwick

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.

Original languageEnglish (US)
Pages (from-to)389-391
Number of pages3
JournalCancer Research
Volume58
Issue number3
StatePublished - Feb 1 1998
Externally publishedYes

Fingerprint

Hyperplasia
Prostate
Allelic Imbalance
Carcinoma
Microdissection
Paraffin
Microsatellite Repeats
Formaldehyde
Carcinogenesis
Chromosomes
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cheng, L., Shan, A., Cheville, J. C., Qian, J., & Bostwick, D. G. (1998). Atypical adenomatous hyperplasia of the prostate: A premalignant lesion? Cancer Research, 58(3), 389-391.

Atypical adenomatous hyperplasia of the prostate : A premalignant lesion? / Cheng, Liang; Shan, Ailin; Cheville, John C.; Qian, Junqi; Bostwick, David G.

In: Cancer Research, Vol. 58, No. 3, 01.02.1998, p. 389-391.

Research output: Contribution to journalArticle

Cheng, L, Shan, A, Cheville, JC, Qian, J & Bostwick, DG 1998, 'Atypical adenomatous hyperplasia of the prostate: A premalignant lesion?', Cancer Research, vol. 58, no. 3, pp. 389-391.
Cheng L, Shan A, Cheville JC, Qian J, Bostwick DG. Atypical adenomatous hyperplasia of the prostate: A premalignant lesion? Cancer Research. 1998 Feb 1;58(3):389-391.
Cheng, Liang ; Shan, Ailin ; Cheville, John C. ; Qian, Junqi ; Bostwick, David G. / Atypical adenomatous hyperplasia of the prostate : A premalignant lesion?. In: Cancer Research. 1998 ; Vol. 58, No. 3. pp. 389-391.
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