Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response

Sunitha Rangaraju, Gregory M. Solis, Sofia I. Andersson, Rafael L. Gomez-Amaro, Rozina Kardakaris, Caroline D. Broaddus, Alexander Niculescu, Michael Petrascheck

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Oxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by atypical antidepressants depends on synaptic transmission, the activation by reactive oxygen species does not. Lifespan extension by atypical antidepressants depends on the neuronal oxidative stress response activation mechanism. Neuronal regulation of the oxidative stress response is likely to have evolved as a survival mechanism to protect the organism from oxidative stress, upon detection of adverse or dangerous conditions by the nervous system.

Original languageEnglish (US)
Pages (from-to)971-981
Number of pages11
JournalAging Cell
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Second-Generation Antidepressive Agents
Caenorhabditis elegans
Oxidative Stress
Synaptic Transmission
Psychotic Disorders
Nervous System
Antidepressive Agents
Antipsychotic Agents
Psychiatry
Reactive Oxygen Species
Depression

Keywords

  • Anti-aging
  • Antidepressant
  • Caenorhabditis elegans
  • Non-cell-autonomous
  • Psychiatric disease
  • Signal transduction
  • Stress
  • Synaptic transmission

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Rangaraju, S., Solis, G. M., Andersson, S. I., Gomez-Amaro, R. L., Kardakaris, R., Broaddus, C. D., ... Petrascheck, M. (2015). Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell, 14(6), 971-981. https://doi.org/10.1111/acel.12379

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. / Rangaraju, Sunitha; Solis, Gregory M.; Andersson, Sofia I.; Gomez-Amaro, Rafael L.; Kardakaris, Rozina; Broaddus, Caroline D.; Niculescu, Alexander; Petrascheck, Michael.

In: Aging Cell, Vol. 14, No. 6, 01.12.2015, p. 971-981.

Research output: Contribution to journalArticle

Rangaraju, S, Solis, GM, Andersson, SI, Gomez-Amaro, RL, Kardakaris, R, Broaddus, CD, Niculescu, A & Petrascheck, M 2015, 'Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response', Aging Cell, vol. 14, no. 6, pp. 971-981. https://doi.org/10.1111/acel.12379
Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD et al. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell. 2015 Dec 1;14(6):971-981. https://doi.org/10.1111/acel.12379
Rangaraju, Sunitha ; Solis, Gregory M. ; Andersson, Sofia I. ; Gomez-Amaro, Rafael L. ; Kardakaris, Rozina ; Broaddus, Caroline D. ; Niculescu, Alexander ; Petrascheck, Michael. / Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. In: Aging Cell. 2015 ; Vol. 14, No. 6. pp. 971-981.
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