Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response

Sunitha Rangaraju, Gregory M. Solis, Sofia I. Andersson, Rafael L. Gomez-Amaro, Rozina Kardakaris, Caroline D. Broaddus, Alexander B. Niculescu, Michael Petrascheck

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Oxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by atypical antidepressants depends on synaptic transmission, the activation by reactive oxygen species does not. Lifespan extension by atypical antidepressants depends on the neuronal oxidative stress response activation mechanism. Neuronal regulation of the oxidative stress response is likely to have evolved as a survival mechanism to protect the organism from oxidative stress, upon detection of adverse or dangerous conditions by the nervous system.

Original languageEnglish (US)
Pages (from-to)971-981
Number of pages11
JournalAging Cell
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2015

Keywords

  • Anti-aging
  • Antidepressant
  • Caenorhabditis elegans
  • Non-cell-autonomous
  • Psychiatric disease
  • Signal transduction
  • Stress
  • Synaptic transmission

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Fingerprint Dive into the research topics of 'Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response'. Together they form a unique fingerprint.

  • Cite this

    Rangaraju, S., Solis, G. M., Andersson, S. I., Gomez-Amaro, R. L., Kardakaris, R., Broaddus, C. D., Niculescu, A. B., & Petrascheck, M. (2015). Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell, 14(6), 971-981. https://doi.org/10.1111/acel.12379