Auditory P300 Abnormalities and Left Posterior Superior Temporal Gyrus Volume Reduction in Schizophrenia

Robert W. McCarley, Martha E. Shenton, Brian O'Donnell, Stephen F. Faux, Ron Kikinis, Paul G. Nestor, Ferenc A. Jolesz

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

Abnormalities in the auditory P300 event-related potential are one of the most robust findings in schizophrenia. To investigate the brain source(s) of this major functional abnormality, we combined P300 recordings with the use of a new generation of magnetic resonance imaging (MRI) technology to examine specific temporal lobe gray matter regions of interest in schizophrenics and normal controls. In schizophrenics, gray matter volume reductions in the left posterior superior temporal gyrus (STG), which includes Heschl's gyrus and the planum temporale, were highly and specifically associated with both P300 amplitude reduction and left

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalArchives of General Psychiatry
Volume50
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

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Schizophrenia
P300 Event-Related Potentials
Auditory Cortex
Temazepam
Temporal Lobe
Magnetic Resonance Imaging
Technology
Brain
Wernicke Area
Gray Matter
Grey Matter
Hearing
Planum Temporale
Event-related Potentials

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Auditory P300 Abnormalities and Left Posterior Superior Temporal Gyrus Volume Reduction in Schizophrenia. / McCarley, Robert W.; Shenton, Martha E.; O'Donnell, Brian; Faux, Stephen F.; Kikinis, Ron; Nestor, Paul G.; Jolesz, Ferenc A.

In: Archives of General Psychiatry, Vol. 50, No. 3, 1993, p. 190-197.

Research output: Contribution to journalArticle

McCarley, Robert W. ; Shenton, Martha E. ; O'Donnell, Brian ; Faux, Stephen F. ; Kikinis, Ron ; Nestor, Paul G. ; Jolesz, Ferenc A. / Auditory P300 Abnormalities and Left Posterior Superior Temporal Gyrus Volume Reduction in Schizophrenia. In: Archives of General Psychiatry. 1993 ; Vol. 50, No. 3. pp. 190-197.
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