Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction

David S. Wilkes

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalSeminars in Immunology
Volume24
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • Antibody mediated rejection
  • Autoimmunity
  • IL-17
  • Lung transplantation
  • Obliterative bronchiolitis
  • Primary graft dysfunction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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