Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction

David S. Wilkes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lung transplantation is considered a definitive treatment for many lung diseases. However, rejection and other pathologic entities are major causes of morbidity and mortality for lung transplant recipients. Primary graft dysfunction (PGD) and obliterative bronchiolitis (OB) are the leading causes of early and late mortality, respectively. While the immune basis of PGD has not been clearly defined, evidence is emerging about roles for autoantibodies in this process. Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalSeminars in Immunology
Volume24
Issue number2
DOIs
StatePublished - Apr 2012

Fingerprint

Primary Graft Dysfunction
Bronchiolitis
Autoantibodies
Lung Transplantation
Mortality
Autoimmunity
Lung Diseases
Morbidity
Lung
Therapeutics

Keywords

  • Antibody mediated rejection
  • Autoimmunity
  • IL-17
  • Lung transplantation
  • Obliterative bronchiolitis
  • Primary graft dysfunction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction. / Wilkes, David S.

In: Seminars in Immunology, Vol. 24, No. 2, 04.2012, p. 131-135.

Research output: Contribution to journalArticle

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