Autoimmune Hepatitis

Cristina D. Cole, Romil Saxena

Research output: Contribution to journalReview article

1 Scopus citations


Autoimmune hepatitis is a chronic necroinflammatory disease of unknown etiology that is characterized by increased aminotransferases, serum autoantibodies, increased immunoglobulin G levels, and histological interface hepatitis. The disease does not have a pathognomonic clinical, laboratory, or histological feature; diagnosis depends on a combination of clinical and pathologic criteria which also form the basis for a weighted scoring system to aid diagnosis. Liver biopsy is an essential part of the diagnostic criteria and is also crucial to the management of the disease. This review focuses on the diagnosis, microscopic features, differential diagnosis and overlap syndromes of autoimmune hepatitis.

Original languageEnglish (US)
Pages (from-to)259-276
Number of pages18
JournalSurgical Pathology Clinics
Issue number2
StatePublished - Jun 1 2013


  • Autoantibodies
  • Autoimmune hepatitis
  • Chronic hepatitis
  • Diagnostic criteria
  • Differential diagnosis
  • Histology
  • Interface hepatitis
  • Overlap syndrome

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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