Autoimmune Hepatitis in the Elderly

Diagnosis and Pharmacologic Management

Syed Rizvi, Samer Gawrieh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Autoimmune hepatitis (AIH) may present as acute or chronic hepatitis in the elderly. Advanced hepatic fibrosis and cirrhosis are common on first presentation in this population. In this review, we discuss the presentation, approach to diagnosis and management of AIH in the elderly. As polypharmacy is common in the elderly, careful medication use history is essential for detecting drug-induced AIH-like hepatitis. Steroid-sparing or minimizing therapeutic regimens are preferred to treat AIH in the elderly. For the purpose of induction, budesonide or lower dose prednisone in combination with azathioprine (AZA) regimens are preferred over high-dose prednisone monotherapy due to the higher risk of side effects of the later in the elderly. The goal of maintenance therapy should be to achieve full biochemical and histologic remission. Bone density monitoring and interventions to prevent steroid-related bone disease should be implemented throughout the course of the disease. Liver transplantation should be considered in the elderly patient with liver failure or early hepatocellular carcinoma if there are no significant comorbidities or compromise in functional status.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalDrugs and Aging
DOIs
StateAccepted/In press - Jul 4 2018

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Autoimmune Hepatitis
Prednisone
Steroids
Essential Drugs
Chemical and Drug Induced Liver Injury
Polypharmacy
Budesonide
Bone Diseases
Liver Failure
Azathioprine
Chronic Hepatitis
Liver Cirrhosis
Liver Transplantation
Bone Density
Hepatitis
Comorbidity
Hepatocellular Carcinoma
Fibrosis
History
Therapeutics

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology (medical)

Cite this

Autoimmune Hepatitis in the Elderly : Diagnosis and Pharmacologic Management. / Rizvi, Syed; Gawrieh, Samer.

In: Drugs and Aging, 04.07.2018, p. 1-14.

Research output: Contribution to journalArticle

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