Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro

G. David Roodman, J. L. Ascensao, M. Banisadre, P. M. Bloom, E. D. Zanjani

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A patient with autoimmune renal failure, cavitary lung lesions and arthritis experienced pancytopenia while prednisone therapy was being tapered. Utilizing semisolid culture techniques, a population of nonahderent peripheral blood mononuclear cells was demonstrated, which inhibited autologous but not allogenic bone marrow erythroid colony-forming units (CFU-E) and myeloid colony-forming units (CFU-c) in vitro. No inhibition of CFU-E or CFU-c colony formation was seen when patient's serum or immunoglobulin G (IgG) was added to cultures. Reinstitution of prednisone therapy resulted in normalization of peripheral blood counts, which was accompanied by the loss of the hemopoietic inhibitor cell activity in the patient's peripheral blood. These results demonstrate the need for testing autologous marrow samples when looking for possible immune-mediated inhibition of hematopioesis.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalThe American Journal of Medicine
Volume69
Issue number2
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Erythroid Precursor Cells
Pancytopenia
Bone Development
Bone Marrow
Lymphocytes
Prednisone
Culture Techniques
Arthritis
Renal Insufficiency
Blood Cells
Stem Cells
Immunoglobulin G
Lung
Therapeutics
Serum
Population
In Vitro Techniques

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro. / Roodman, G. David; Ascensao, J. L.; Banisadre, M.; Bloom, P. M.; Zanjani, E. D.

In: The American Journal of Medicine, Vol. 69, No. 2, 1980, p. 325-328.

Research output: Contribution to journalArticle

Roodman, G. David ; Ascensao, J. L. ; Banisadre, M. ; Bloom, P. M. ; Zanjani, E. D. / Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro. In: The American Journal of Medicine. 1980 ; Vol. 69, No. 2. pp. 325-328.
@article{f40bd1ae1dc64f79b8b4fe51c62c5b73,
title = "Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro",
abstract = "A patient with autoimmune renal failure, cavitary lung lesions and arthritis experienced pancytopenia while prednisone therapy was being tapered. Utilizing semisolid culture techniques, a population of nonahderent peripheral blood mononuclear cells was demonstrated, which inhibited autologous but not allogenic bone marrow erythroid colony-forming units (CFU-E) and myeloid colony-forming units (CFU-c) in vitro. No inhibition of CFU-E or CFU-c colony formation was seen when patient's serum or immunoglobulin G (IgG) was added to cultures. Reinstitution of prednisone therapy resulted in normalization of peripheral blood counts, which was accompanied by the loss of the hemopoietic inhibitor cell activity in the patient's peripheral blood. These results demonstrate the need for testing autologous marrow samples when looking for possible immune-mediated inhibition of hematopioesis.",
author = "Roodman, {G. David} and Ascensao, {J. L.} and M. Banisadre and Bloom, {P. M.} and Zanjani, {E. D.}",
year = "1980",
doi = "10.1016/0002-9343(80)90393-9",
language = "English",
volume = "69",
pages = "325--328",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro

AU - Roodman, G. David

AU - Ascensao, J. L.

AU - Banisadre, M.

AU - Bloom, P. M.

AU - Zanjani, E. D.

PY - 1980

Y1 - 1980

N2 - A patient with autoimmune renal failure, cavitary lung lesions and arthritis experienced pancytopenia while prednisone therapy was being tapered. Utilizing semisolid culture techniques, a population of nonahderent peripheral blood mononuclear cells was demonstrated, which inhibited autologous but not allogenic bone marrow erythroid colony-forming units (CFU-E) and myeloid colony-forming units (CFU-c) in vitro. No inhibition of CFU-E or CFU-c colony formation was seen when patient's serum or immunoglobulin G (IgG) was added to cultures. Reinstitution of prednisone therapy resulted in normalization of peripheral blood counts, which was accompanied by the loss of the hemopoietic inhibitor cell activity in the patient's peripheral blood. These results demonstrate the need for testing autologous marrow samples when looking for possible immune-mediated inhibition of hematopioesis.

AB - A patient with autoimmune renal failure, cavitary lung lesions and arthritis experienced pancytopenia while prednisone therapy was being tapered. Utilizing semisolid culture techniques, a population of nonahderent peripheral blood mononuclear cells was demonstrated, which inhibited autologous but not allogenic bone marrow erythroid colony-forming units (CFU-E) and myeloid colony-forming units (CFU-c) in vitro. No inhibition of CFU-E or CFU-c colony formation was seen when patient's serum or immunoglobulin G (IgG) was added to cultures. Reinstitution of prednisone therapy resulted in normalization of peripheral blood counts, which was accompanied by the loss of the hemopoietic inhibitor cell activity in the patient's peripheral blood. These results demonstrate the need for testing autologous marrow samples when looking for possible immune-mediated inhibition of hematopioesis.

UR - http://www.scopus.com/inward/record.url?scp=0018942194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018942194&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(80)90393-9

DO - 10.1016/0002-9343(80)90393-9

M3 - Article

C2 - 7405950

AN - SCOPUS:0018942194

VL - 69

SP - 325

EP - 328

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 2

ER -