Autologous fibrin gel: Bactericidal properties in contaminated hepatic injury

Scott A. Dulchavsky, Evan R. Geller, James Maurer, P. R. Kennedy, George T. Tortora, Subir R. Maitra

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Fibrin glue is an effective hemostatic agent in a variety of clinical situations; its utility is limited by potential transmission of viral infection. We studied the bactericidal properties of fibrin gel (FG) in a murine contaminated hepatic injury model and in vitro by agar plate culture method. Intra-abdominal abscess formation and adhesion rate were assessed following controlled liver injury in association with abdominal contamination with 107 Bacteroides fragilis and hepatorrhaphy (H, n = 15) or FG (n = 12). Animals treated by hepatorrhaphy had a significantly greater intra-abdominal abscess rate (15/15 vs. 4/12, p < 0.05) and adhesion rate (14/15 vs. 6/12, p < 0.05) than animals treated with FG. Fibrin gel is bactericidal to Bacteroides fragilis, Enterobacter faecium, Escherichia coli, and Staphylococcus aureus but has no effect against Klebsiella pneumoniae or Pseudomonas aeruginosa; the plasma component appears active. Fibrin gel demonstrates significant improvement in adhesion formation and intra-abdominal abscess rate when compared with suture hepatorrhaphy. Fibrin gel appears protective in contaminated hepatic injury.

Original languageEnglish (US)
Pages (from-to)991-995
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume31
Issue number7
DOIs
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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    Dulchavsky, S. A., Geller, E. R., Maurer, J., Kennedy, P. R., Tortora, G. T., & Maitra, S. R. (1991). Autologous fibrin gel: Bactericidal properties in contaminated hepatic injury. Journal of Trauma - Injury, Infection and Critical Care, 31(7), 991-995. https://doi.org/10.1097/00005373-199107000-00019