Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource

B. Peters, S. Dirscherl, J. Dantzer, J. Nowacki, S. Cross, X. Li, K. Cornetta, M. C. Dinauer, S. D. Mooney

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Research in gene therapy involving genome-integrating vectors now often includes analysis of vector integration sites across the genome using methods such as ligation-mediated PCR (LM-PCR) or linear amplification-mediated PCR (LAM-PCR). To help researchers analyze these sites and the functions of nearby genes, we have developed SeqMap (http://seqmap.compbio.iupui.edu/) a secure, web-based comprehensive vector integration site management tool that automatically analyzes and annotates large numbers of vector integration sites derived from LM-PCR experiments in human and model organisms upon a common genome database. We believe the use of this resource will enable better reproducibility and understanding of this important data.

Original languageEnglish (US)
Pages (from-to)1294-1298
Number of pages5
JournalGene Therapy
Volume15
Issue number18
DOIs
StatePublished - Jun 27 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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    Peters, B., Dirscherl, S., Dantzer, J., Nowacki, J., Cross, S., Li, X., Cornetta, K., Dinauer, M. C., & Mooney, S. D. (2008). Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource. Gene Therapy, 15(18), 1294-1298. https://doi.org/10.1038/gt.2008.99