Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis

S. Fang, J. McLaughlin, J. Fang, J. Huang, I. Autti-Rämö, Å Fagerlund, S. W. Jacobson, L. K. Robinson, H. E. Hoyme, S. N. Mattson, E. Riley, F. Zhou, R. Ward, E. S. Moore, T. Foroud

Research output: Contribution to journalArticle

27 Scopus citations


Objectives - Use three-dimensional (3D) facial laser scanned images from children with fetal alcohol syndrome (FAS) and controls to develop an automated diagnosis technique that can reliably and accurately identify individuals prenatally exposed to alcohol. Methods - A detailed dysmorphology evaluation, history of prenatal alcohol exposure, and 3D facial laser scans were obtained from 149 individuals (86 FAS; 63 Control) recruited from two study sites (Cape Town, South Africa and Helsinki, Finland). Computer graphics, machine learning, and pattern recognition techniques were used to automatically identify a set of facial features that best discriminated individuals with FAS from controls in each sample. Results - An automated feature detection and analysis technique was developed and applied to the two study populations. A unique set of facial regions and features were identified for each population that accurately discriminated FAS and control faces without any human intervention. Conclusion - Our results demonstrate that computer algorithms can be used to automatically detect facial features that can discriminate FAS and control faces.

Original languageEnglish (US)
Pages (from-to)162-171
Number of pages10
JournalOrthodontics and Craniofacial Research
Issue number3
StatePublished - Aug 1 2008
Externally publishedYes


  • Fetal alcohol syndrome
  • Geometric feature extraction
  • Image analysis
  • Machine learning
  • Pattern classification

ASJC Scopus subject areas

  • Orthodontics
  • Oral Surgery
  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

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  • Cite this

    Fang, S., McLaughlin, J., Fang, J., Huang, J., Autti-Rämö, I., Fagerlund, Å., Jacobson, S. W., Robinson, L. K., Hoyme, H. E., Mattson, S. N., Riley, E., Zhou, F., Ward, R., Moore, E. S., & Foroud, T. (2008). Automated diagnosis of fetal alcohol syndrome using 3D facial image analysis. Orthodontics and Craniofacial Research, 11(3), 162-171.