Automated region definition for cardiac nitrogen-13-ammonia PET imaging

O. Muzik, R. Beanlands, E. Wolfe, Gary Hutchins, M. Schwaiger

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

In combination with PET, the tracer 13N-ammonia can be employed for the noninvasive quantification of myocardial perfusion at rest and after pharmacological stress. The purpose of this study was to develop an analysis method for the quantification of regional myocardial blood flow in the clinical setting. The algorithm includes correction for patient motion, an automated definition of multiple regions and display of absolute flows in polar map format. The effects of partial volume and blood to tissue cross- contamination were accounted for by optimizing the radial position of regions to meet fundamental assumptions of the kinetic model. In order to correct for motion artifacts, the myocardial displacement was manually determined based on edge-enhanced images. The obtained results exhibit the capability of the presented algorithm to noninvasively assess regional myocardial perfusion in the clinical environment.

Original languageEnglish (US)
Pages (from-to)336-344
Number of pages9
JournalJournal of Nuclear Medicine
Volume34
Issue number2
StatePublished - 1993
Externally publishedYes

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Ammonia
Nitrogen
Perfusion
Regional Blood Flow
Blood Volume
Artifacts
Pharmacology

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Muzik, O., Beanlands, R., Wolfe, E., Hutchins, G., & Schwaiger, M. (1993). Automated region definition for cardiac nitrogen-13-ammonia PET imaging. Journal of Nuclear Medicine, 34(2), 336-344.

Automated region definition for cardiac nitrogen-13-ammonia PET imaging. / Muzik, O.; Beanlands, R.; Wolfe, E.; Hutchins, Gary; Schwaiger, M.

In: Journal of Nuclear Medicine, Vol. 34, No. 2, 1993, p. 336-344.

Research output: Contribution to journalArticle

Muzik, O, Beanlands, R, Wolfe, E, Hutchins, G & Schwaiger, M 1993, 'Automated region definition for cardiac nitrogen-13-ammonia PET imaging', Journal of Nuclear Medicine, vol. 34, no. 2, pp. 336-344.
Muzik, O. ; Beanlands, R. ; Wolfe, E. ; Hutchins, Gary ; Schwaiger, M. / Automated region definition for cardiac nitrogen-13-ammonia PET imaging. In: Journal of Nuclear Medicine. 1993 ; Vol. 34, No. 2. pp. 336-344.
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