Autonomic nerve activity and blood pressure in ambulatory dogs

Jessica Hellyer, A. George Akingba, Kyoung Suk Rhee, Alex Y. Tan, Kathleen A. Lane, Changyu Shen, Jheel Patel, Michael C. Fishbein, Peng Sheng Chen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background The relationship between cardiac autonomic nerve activity and blood pressure (BP) changes in ambulatory dogs is unclear. Objective The purpose of this study was to test the hypotheses that simultaneous termination of stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA) predisposes to spontaneous orthostatic hypotension and that specific β2-adrenoceptor blockade prevents the hypotensive episodes. Methods We used a radiotransmitter to record SGNA, VNA, and BP in eight ambulatory dogs. Video imaging was used to document postural changes. Results Of these eight dogs, five showed simultaneous sympathovagal discharges in which the minute-by-minute integrated SGNA correlated with integrated VNA in a linear pattern (group 1). In these dogs, abrupt termination of simultaneous SGNA-VNA at the time of postural changes (as documented by video imaging) was followed by abrupt (>20 mm Hg over four beats) drops in BP. Dogs without simultaneous on/off firing (group 2) did not have drastic drops in pressure. ICI-118,551 (ICI, a specific β2-blocker) infused at 3 μg/kg/h for 7 days significantly increased BP from 126 mm Hg (95% confidence interval 118-133) to 133 mm Hg (95% confidence interval 125-141; P =.0001). The duration of hypotension (mean systolic BP <100 mm Hg) during baseline accounted for 7.1% of the recording. The percentage was reduced by ICI to 1.3% (P =.01). Conclusion Abrupt simultaneous termination of SGNA-VNA was observed at the time of orthostatic hypotension in ambulatory dogs. Selective β2- adrenoceptor blockade increased BP and reduced the duration of hypotension in this model.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalHeart Rhythm
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2014

Keywords

  • Ambulatory nerve recording
  • Beta-blockade
  • Orthostatic hypotension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Hellyer, J., George Akingba, A., Rhee, K. S., Tan, A. Y., Lane, K. A., Shen, C., Patel, J., Fishbein, M. C., & Chen, P. S. (2014). Autonomic nerve activity and blood pressure in ambulatory dogs. Heart Rhythm, 11(2), 307-313. https://doi.org/10.1016/j.hrthm.2013.11.022