Autonomic nervous system in ventricular arrhythmia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In spite of recent advances in cardiovascular medicine, sudden cardiac death (SCD) remains a major public health problem. Because there is increased risk of SCDs in patients with coronary artery diseases and myocardial infarction (MI), the electrical and anatomical remodeling created by infarction has been a focus of research in the mechanisms of SCD. There is a circadian variation of the incidence of SCD. Beta blocker therapy abolishes this circadian pattern. These data suggest that, in addition to anatomical and electrical remodeling, neural remodeling may also play a role in the generation of SCD. We propose that nerve sprouting occurs after myocardial infarction, and that the increased sympathetic nerve activity contributes to the development of SCD. Histopathological studies showed that there are increased sympathetic nerve densities in the heart, consistent with cardiac nerve sprouting. Direct stellate ganglion nerve activity (SGNA) recording showed that there is a direct temporal relationship between SGNA and the development of ventricular arrhythmias and SCD in ambulatory dogs. These findings suggest that autonomic nervous system remodeling and sympathetic nerve activities directly contribute to the development of SCD.

Original languageEnglish
Title of host publicationVentricular Arrhythmia: From Principles to Patients
PublisherNova Science Publishers, Inc.
Pages173-179
Number of pages7
ISBN (Print)9781620815403
StatePublished - Feb 2013

Fingerprint

Autonomic Nervous System
Sudden Cardiac Death
Cardiac Arrhythmias
Atrial Remodeling
Stellate Ganglion
Infarction
Public Health
Myocardial Infarction
Medicine
Dogs
Incidence
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chen, L., & Chen, P-S. (2013). Autonomic nervous system in ventricular arrhythmia. In Ventricular Arrhythmia: From Principles to Patients (pp. 173-179). Nova Science Publishers, Inc..

Autonomic nervous system in ventricular arrhythmia. / Chen, Lan; Chen, Peng-Sheng.

Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., 2013. p. 173-179.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chen, L & Chen, P-S 2013, Autonomic nervous system in ventricular arrhythmia. in Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., pp. 173-179.
Chen L, Chen P-S. Autonomic nervous system in ventricular arrhythmia. In Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc. 2013. p. 173-179
Chen, Lan ; Chen, Peng-Sheng. / Autonomic nervous system in ventricular arrhythmia. Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., 2013. pp. 173-179
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