Abstract
In spite of recent advances in cardiovascular medicine, sudden cardiac death (SCD) remains a major public health problem. Because there is increased risk of SCDs in patients with coronary artery diseases and myocardial infarction (MI), the electrical and anatomical remodeling created by infarction has been a focus of research in the mechanisms of SCD. There is a circadian variation of the incidence of SCD. Beta blocker therapy abolishes this circadian pattern. These data suggest that, in addition to anatomical and electrical remodeling, neural remodeling may also play a role in the generation of SCD. We propose that nerve sprouting occurs after myocardial infarction, and that the increased sympathetic nerve activity contributes to the development of SCD. Histopathological studies showed that there are increased sympathetic nerve densities in the heart, consistent with cardiac nerve sprouting. Direct stellate ganglion nerve activity (SGNA) recording showed that there is a direct temporal relationship between SGNA and the development of ventricular arrhythmias and SCD in ambulatory dogs. These findings suggest that autonomic nervous system remodeling and sympathetic nerve activities directly contribute to the development of SCD.
| Original language | English |
|---|---|
| Title of host publication | Ventricular Arrhythmia: From Principles to Patients |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 173-179 |
| Number of pages | 7 |
| ISBN (Print) | 9781620815403 |
| State | Published - Feb 2013 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Autonomic nervous system in ventricular arrhythmia. / Chen, Lan; Chen, Peng-Sheng.
Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., 2013. p. 173-179.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Autonomic nervous system in ventricular arrhythmia
AU - Chen, Lan
AU - Chen, Peng-Sheng
PY - 2013/2
Y1 - 2013/2
N2 - In spite of recent advances in cardiovascular medicine, sudden cardiac death (SCD) remains a major public health problem. Because there is increased risk of SCDs in patients with coronary artery diseases and myocardial infarction (MI), the electrical and anatomical remodeling created by infarction has been a focus of research in the mechanisms of SCD. There is a circadian variation of the incidence of SCD. Beta blocker therapy abolishes this circadian pattern. These data suggest that, in addition to anatomical and electrical remodeling, neural remodeling may also play a role in the generation of SCD. We propose that nerve sprouting occurs after myocardial infarction, and that the increased sympathetic nerve activity contributes to the development of SCD. Histopathological studies showed that there are increased sympathetic nerve densities in the heart, consistent with cardiac nerve sprouting. Direct stellate ganglion nerve activity (SGNA) recording showed that there is a direct temporal relationship between SGNA and the development of ventricular arrhythmias and SCD in ambulatory dogs. These findings suggest that autonomic nervous system remodeling and sympathetic nerve activities directly contribute to the development of SCD.
AB - In spite of recent advances in cardiovascular medicine, sudden cardiac death (SCD) remains a major public health problem. Because there is increased risk of SCDs in patients with coronary artery diseases and myocardial infarction (MI), the electrical and anatomical remodeling created by infarction has been a focus of research in the mechanisms of SCD. There is a circadian variation of the incidence of SCD. Beta blocker therapy abolishes this circadian pattern. These data suggest that, in addition to anatomical and electrical remodeling, neural remodeling may also play a role in the generation of SCD. We propose that nerve sprouting occurs after myocardial infarction, and that the increased sympathetic nerve activity contributes to the development of SCD. Histopathological studies showed that there are increased sympathetic nerve densities in the heart, consistent with cardiac nerve sprouting. Direct stellate ganglion nerve activity (SGNA) recording showed that there is a direct temporal relationship between SGNA and the development of ventricular arrhythmias and SCD in ambulatory dogs. These findings suggest that autonomic nervous system remodeling and sympathetic nerve activities directly contribute to the development of SCD.
UR - http://www.scopus.com/inward/record.url?scp=84895281366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895281366&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84895281366
SN - 9781620815403
SP - 173
EP - 179
BT - Ventricular Arrhythmia: From Principles to Patients
PB - Nova Science Publishers, Inc.
ER -