Autophagy

Hao Zhang, Bilon Khambu, Xiao-Ming Yin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases: Third Edition
PublisherWiley Blackwell
Pages151-165
Number of pages15
ISBN (Print)9781118663387, 9781118663394
DOIs
StatePublished - Sep 28 2015

Keywords

  • Atg proteins
  • Beclin
  • Lysosomes
  • Mitophagy
  • Phagosomes
  • Ubiquitin
  • α1-antitrypsin

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Zhang, H., Khambu, B., & Yin, X-M. (2015). Autophagy. In Signaling Pathways in Liver Diseases: Third Edition (pp. 151-165). Wiley Blackwell. https://doi.org/10.1002/9781118663387.ch11