Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.
- Atg proteins
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