Autophagy

Hao Zhang, Bilon Khambu, Xiao-Ming Yin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases: Third Edition
PublisherWiley Blackwell
Pages151-165
Number of pages15
ISBN (Print)9781118663387, 9781118663394
DOIs
StatePublished - Sep 28 2015

Fingerprint

Autophagy
Liver
Alcoholic Fatty Liver
Hepatitis
Liver Diseases
Hepatocytes
Hepatocellular Carcinoma
Wounds and Injuries
Genes

Keywords

  • Atg proteins
  • Beclin
  • Lysosomes
  • Mitophagy
  • Phagosomes
  • Ubiquitin
  • α1-antitrypsin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zhang, H., Khambu, B., & Yin, X-M. (2015). Autophagy. In Signaling Pathways in Liver Diseases: Third Edition (pp. 151-165). Wiley Blackwell. https://doi.org/10.1002/9781118663387.ch11

Autophagy. / Zhang, Hao; Khambu, Bilon; Yin, Xiao-Ming.

Signaling Pathways in Liver Diseases: Third Edition. Wiley Blackwell, 2015. p. 151-165.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zhang, H, Khambu, B & Yin, X-M 2015, Autophagy. in Signaling Pathways in Liver Diseases: Third Edition. Wiley Blackwell, pp. 151-165. https://doi.org/10.1002/9781118663387.ch11
Zhang H, Khambu B, Yin X-M. Autophagy. In Signaling Pathways in Liver Diseases: Third Edition. Wiley Blackwell. 2015. p. 151-165 https://doi.org/10.1002/9781118663387.ch11
Zhang, Hao ; Khambu, Bilon ; Yin, Xiao-Ming. / Autophagy. Signaling Pathways in Liver Diseases: Third Edition. Wiley Blackwell, 2015. pp. 151-165
@inbook{1ce0c112ac5849ffb342c0be1c797746,
title = "Autophagy",
abstract = "Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.",
keywords = "Atg proteins, Beclin, Lysosomes, Mitophagy, Phagosomes, Ubiquitin, α1-antitrypsin",
author = "Hao Zhang and Bilon Khambu and Xiao-Ming Yin",
year = "2015",
month = "9",
day = "28",
doi = "10.1002/9781118663387.ch11",
language = "English (US)",
isbn = "9781118663387",
pages = "151--165",
booktitle = "Signaling Pathways in Liver Diseases: Third Edition",
publisher = "Wiley Blackwell",

}

TY - CHAP

T1 - Autophagy

AU - Zhang, Hao

AU - Khambu, Bilon

AU - Yin, Xiao-Ming

PY - 2015/9/28

Y1 - 2015/9/28

N2 - Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.

AB - Autophagy is a basic cellular process actively promoting turnover in hepatocytes. More than 30 autophagy genes have been identified since the 1990s. The autophagy process is finely regulated in both its activation and degradation. Recent studies have unveiled autophagy's important role in hepatic physiology and liver pathogenesis including hepatitis, hepatocellular carcinoma and alcoholic and nonalcoholic fatty liver disease, liver injury, etc. Regulation of autophagy could potentially be explored as a treatment option for liver diseases.

KW - Atg proteins

KW - Beclin

KW - Lysosomes

KW - Mitophagy

KW - Phagosomes

KW - Ubiquitin

KW - α1-antitrypsin

UR - http://www.scopus.com/inward/record.url?scp=84946750090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946750090&partnerID=8YFLogxK

U2 - 10.1002/9781118663387.ch11

DO - 10.1002/9781118663387.ch11

M3 - Chapter

AN - SCOPUS:84946750090

SN - 9781118663387

SN - 9781118663394

SP - 151

EP - 165

BT - Signaling Pathways in Liver Diseases: Third Edition

PB - Wiley Blackwell

ER -