Autophagy in alcoholic liver disease, self-eating triggered by drinking

Lin Wang, Bilon Khambu, Hao Zhang, Xiao Ming Yin

Research output: Contribution to journalShort survey

21 Scopus citations

Abstract

Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cellular function and also plays critical roles in the etiology and pathogenesis of a number of human diseases. In alcohol-induced liver disease, autophagy is a protective mechanism against the liver injury caused by alcohol. Autophagy is activated in acute ethanol treatment but could be suppressed in chronic and/or high dose treatment of alcohol. The selective removal of lipid droplets and/or damaged mitochondria is likely the major mode of autophagy in reducing liver injury. Understanding the dynamics of the autophagy process and the approach to modulate autophagy could help finding new ways to battle against alcohol-induced liver injury.

Original languageEnglish (US)
Pages (from-to)S2-S6
JournalClinics and Research in Hepatology and Gastroenterology
Volume39
DOIs
StatePublished - Sep 1 2015

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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