Autophagy in alcoholic liver disease, self-eating triggered by drinking

Lin Wang, Bilon Khambu, Hao Zhang, Xiao-Ming Yin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cellular function and also plays critical roles in the etiology and pathogenesis of a number of human diseases. In alcohol-induced liver disease, autophagy is a protective mechanism against the liver injury caused by alcohol. Autophagy is activated in acute ethanol treatment but could be suppressed in chronic and/or high dose treatment of alcohol. The selective removal of lipid droplets and/or damaged mitochondria is likely the major mode of autophagy in reducing liver injury. Understanding the dynamics of the autophagy process and the approach to modulate autophagy could help finding new ways to battle against alcohol-induced liver injury.

Original languageEnglish (US)
Pages (from-to)S2-S6
JournalClinics and Research in Hepatology and Gastroenterology
Volume39
DOIs
StatePublished - Sep 1 2015

Fingerprint

Alcoholic Liver Diseases
Autophagy
Drinking
Eating
Alcohols
Liver
Wounds and Injuries
Liver Diseases
Mitochondria
Ethanol

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Autophagy in alcoholic liver disease, self-eating triggered by drinking. / Wang, Lin; Khambu, Bilon; Zhang, Hao; Yin, Xiao-Ming.

In: Clinics and Research in Hepatology and Gastroenterology, Vol. 39, 01.09.2015, p. S2-S6.

Research output: Contribution to journalArticle

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