Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

Bilon Khambu, Shengmin Yan, Nazmul Huda, Gang Liu, Xiao Ming Yin

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Autophagy is an evolutionarily conserved intracellular degradative function that is important for liver homeostasis. Accumulating evidence suggests that autophagy is deregulated during the progression and development of alcoholic and non-alcoholic liver diseases. Impaired autophagy prevents the clearance of excessive lipid droplets (LDs), damaged mitochondria, and toxic protein aggregates, which can be generated during the progression of various liver diseases, thus contributing to the development of steatosis, injury, steatohepatitis, fibrosis, and tumors. In this review, we look at the status of hepatic autophagy during the pathogenesis of alcoholic and non-alcoholic liver diseases. We also examine the mechanisms of defects in autophagy, and the hepato-protective roles of autophagy in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), focusing mainly on steatosis and liver injury. Finally, we discuss the therapeutic potential of autophagy modulating agents for the treatment of these two common liver diseases.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalLiver Research
Volume2
Issue number3
DOIs
StatePublished - Sep 2018

Keywords

  • Alcoholic liver disease (ALD)
  • Autophagy
  • Liver injury
  • Non-alcoholic fatty liver disease (NAFLD)
  • Steatosis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Fingerprint Dive into the research topics of 'Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease'. Together they form a unique fingerprint.

Cite this