Autophagy in the retina

A potential role in age-related macular degeneration

Sayak K. Mitter, Haripriya Vittal Rao, Xiaoping Qi, Jun Cai, Andrew Sugrue, William A. Dunn, Maria B. Grant, Michael E. Boulton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

68 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is associated with multiple genetic and cellular defects which lead to a common endpoint, retinal degeneration. Aging and oxidative stress, significant features in the pathogenesis of AMD, are associated with an increase in damaged intracellular organelles and defective autophagy flux in a range of age-related and neurodegenerative diseases. Autophagy is a key process in the maintenance of cellular homeostasis that serves to remove dysfunctional organelles and proteins. Autophagy proteins are strongly expressed in the retina and there is now strong evidence that mitochondrial damage and defective autophagy are a feature of the aging retina and that this is further exacerbated in AMD. It is apparent that autophagy makes a significant contribution to lipofuscin accumulation in the RPE. Pharmacological manipulation of autophagy may offer an alternative therapeutic target in AMD.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages83-90
Number of pages8
Volume723
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume723
ISSN (Print)00652598

Fingerprint

Autophagy
Macular Degeneration
Retina
Aging of materials
Neurodegenerative diseases
Lipofuscin
Oxidative stress
Proteins
Fluxes
Organelles
Defects
Retinal Degeneration
Neurodegenerative Diseases
Oxidative Stress
Homeostasis
Maintenance
Pharmacology

Keywords

  • Age-Related Macular -Degeneration
  • Autophagy
  • Lipofuscin
  • Mitochondria
  • Oxidative Damage
  • Retina
  • Retinal Pigment Epithelium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mitter, S. K., Rao, H. V., Qi, X., Cai, J., Sugrue, A., Dunn, W. A., ... Boulton, M. E. (2012). Autophagy in the retina: A potential role in age-related macular degeneration. In Advances in Experimental Medicine and Biology (Vol. 723, pp. 83-90). (Advances in Experimental Medicine and Biology; Vol. 723). https://doi.org/10.1007/978-1-4614-0631-0_12

Autophagy in the retina : A potential role in age-related macular degeneration. / Mitter, Sayak K.; Rao, Haripriya Vittal; Qi, Xiaoping; Cai, Jun; Sugrue, Andrew; Dunn, William A.; Grant, Maria B.; Boulton, Michael E.

Advances in Experimental Medicine and Biology. Vol. 723 2012. p. 83-90 (Advances in Experimental Medicine and Biology; Vol. 723).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mitter, SK, Rao, HV, Qi, X, Cai, J, Sugrue, A, Dunn, WA, Grant, MB & Boulton, ME 2012, Autophagy in the retina: A potential role in age-related macular degeneration. in Advances in Experimental Medicine and Biology. vol. 723, Advances in Experimental Medicine and Biology, vol. 723, pp. 83-90. https://doi.org/10.1007/978-1-4614-0631-0_12
Mitter SK, Rao HV, Qi X, Cai J, Sugrue A, Dunn WA et al. Autophagy in the retina: A potential role in age-related macular degeneration. In Advances in Experimental Medicine and Biology. Vol. 723. 2012. p. 83-90. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0631-0_12
Mitter, Sayak K. ; Rao, Haripriya Vittal ; Qi, Xiaoping ; Cai, Jun ; Sugrue, Andrew ; Dunn, William A. ; Grant, Maria B. ; Boulton, Michael E. / Autophagy in the retina : A potential role in age-related macular degeneration. Advances in Experimental Medicine and Biology. Vol. 723 2012. pp. 83-90 (Advances in Experimental Medicine and Biology).
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