Autophagy induced by calcium phosphate precipitates targets damaged endosomes

Xi Chen, Bilon Khambu, Hao Zhang, Wentao Gao, Min Li, Xiaoyun Chen, Tamotsu Yoshimori, Xiao-Ming Yin

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Relationship of autophagosomes with endosomal vesicles varies in different conditions. Results: Calcium phosphate precipitates required endocytosis to induce autophagy, caused endosome damage, and recruited autophagosomes to the damaged vesicles. Conclusion: Damaged endosomes can be targeted by autophagosomes. Significance: Autophagy may play a role in endosomal homeostasis.

Original languageEnglish
Pages (from-to)11162-11174
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

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Endosomes
Autophagy
Precipitates
Endocytosis
Homeostasis
calcium phosphate
Autophagosomes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Autophagy induced by calcium phosphate precipitates targets damaged endosomes. / Chen, Xi; Khambu, Bilon; Zhang, Hao; Gao, Wentao; Li, Min; Chen, Xiaoyun; Yoshimori, Tamotsu; Yin, Xiao-Ming.

In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 11162-11174.

Research output: Contribution to journalArticle

Chen, X, Khambu, B, Zhang, H, Gao, W, Li, M, Chen, X, Yoshimori, T & Yin, X-M 2014, 'Autophagy induced by calcium phosphate precipitates targets damaged endosomes', Journal of Biological Chemistry, vol. 289, no. 16, pp. 11162-11174. https://doi.org/10.1074/jbc.M113.531855
Chen, Xi ; Khambu, Bilon ; Zhang, Hao ; Gao, Wentao ; Li, Min ; Chen, Xiaoyun ; Yoshimori, Tamotsu ; Yin, Xiao-Ming. / Autophagy induced by calcium phosphate precipitates targets damaged endosomes. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 16. pp. 11162-11174.
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