Autophagy induced by calcium phosphate precipitates targets damaged endosomes

Xi Chen, Bilon Khambu, Hao Zhang, Wentao Gao, Min Li, Xiaoyun Chen, Tamotsu Yoshimori, Xiao Ming Yin

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Background: Relationship of autophagosomes with endosomal vesicles varies in different conditions. Results: Calcium phosphate precipitates required endocytosis to induce autophagy, caused endosome damage, and recruited autophagosomes to the damaged vesicles. Conclusion: Damaged endosomes can be targeted by autophagosomes. Significance: Autophagy may play a role in endosomal homeostasis.

Original languageEnglish (US)
Pages (from-to)11162-11174
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Chen, X., Khambu, B., Zhang, H., Gao, W., Li, M., Chen, X., Yoshimori, T., & Yin, X. M. (2014). Autophagy induced by calcium phosphate precipitates targets damaged endosomes. Journal of Biological Chemistry, 289(16), 11162-11174. https://doi.org/10.1074/jbc.M113.531855