Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions

Shengmin Yan, Bilon Khambu, Honghai Hong, Gang Liu, Nazmul Huda, Xiao Ming Yin

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.

Original languageEnglish (US)
JournalInternational journal of molecular sciences
Volume20
Issue number20
DOIs
StatePublished - Oct 11 2019

Fingerprint

Autophagy
metabolism
liver
Metabolism
Liver
Modulators
Liver Diseases
modulators
alcohols
Alcohols
Hepatocytes
Untranslated RNA
Fatty Liver
homeostasis
pathogenesis
Alcohol Drinking
machinery
Crosstalk
Homeostasis
Fibrosis

Keywords

  • alcohol-related liver disease
  • autophagy
  • ncRNA
  • non-parenchymal cell
  • nuclear receptor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Autophagy, Metabolism, and Alcohol-Related Liver Disease : Novel Modulators and Functions. / Yan, Shengmin; Khambu, Bilon; Hong, Honghai; Liu, Gang; Huda, Nazmul; Yin, Xiao Ming.

In: International journal of molecular sciences, Vol. 20, No. 20, 11.10.2019.

Research output: Contribution to journalReview article

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