Autophagy, metabolism, and alcohol-related liver disease: Novel modulators and functions

Shengmin Yan, Bilon Khambu, Honghai Hong, Gang Liu, Nazmul Huda, Xiao Ming Yin

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications. Autophagy is critical to maintain liver homeostasis, but dysfunction of autophagy has been observed in ALD. Generally, autophagy is considered to protect the liver from alcohol-induced injury and steatosis. In this review, we will summarize novel modulators of autophagy in hepatic metabolism and ALD, including autophagy-mediating non-coding RNAs (ncRNAs), and crosstalk of autophagy machinery and nuclear factors. We will also discuss novel functions of autophagy in hepatocytes and non-parenchymal hepatic cells during the pathogenesis of ALD and other liver diseases.

Original languageEnglish (US)
Article number5029
JournalInternational journal of molecular sciences
Volume20
Issue number20
DOIs
StatePublished - Oct 2 2019

Keywords

  • Alcohol-related liver disease
  • Autophagy
  • NcRNA
  • Non-parenchymal cell
  • Nuclear receptor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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