Autophagy participates in the unfolded protein response in Toxoplasma gondii

Hoa Mai Nguyen, Laurence Berry, William Sullivan, Sébastien Besteiro

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

Environmental and genetic perturbations of endoplasmic reticulum (ER) function can lead to the accumulation of unfolded proteins. In these conditions, eukaryotic cells can activate a complex signaling network called the unfolded protein response (UPR) to reduce ER stress and restore cellular homeostasis. Autophagy, a degradation and recycling process, is part of this response. The parasitic protist Toxoplasma gondii is known to be able to activate the UPR upon ER stress, and we now show that this pathway leads to autophagy activation, supporting the idea of a regulated function for canonical autophagy as part of an integrated stress response in the parasites.

Original languageEnglish (US)
Article numberfnx153
JournalFEMS Microbiology Letters
Volume364
Issue number15
DOIs
StatePublished - Aug 1 2017

Fingerprint

Unfolded Protein Response
Autophagy
Toxoplasma
Endoplasmic Reticulum Stress
Protein Unfolding
Recycling
Eukaryotic Cells
Endoplasmic Reticulum
Parasites
Homeostasis

Keywords

  • Autophagy
  • EIF2α
  • Endoplasmic reticulum stress
  • Integrated stress response
  • Toxoplasma
  • Unfolded protein response

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Autophagy participates in the unfolded protein response in Toxoplasma gondii. / Nguyen, Hoa Mai; Berry, Laurence; Sullivan, William; Besteiro, Sébastien.

In: FEMS Microbiology Letters, Vol. 364, No. 15, fnx153, 01.08.2017.

Research output: Contribution to journalLetter

Nguyen, Hoa Mai ; Berry, Laurence ; Sullivan, William ; Besteiro, Sébastien. / Autophagy participates in the unfolded protein response in Toxoplasma gondii. In: FEMS Microbiology Letters. 2017 ; Vol. 364, No. 15.
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