Autophagy participates in the unfolded protein response in Toxoplasma gondii

Hoa Mai Nguyen, Laurence Berry, William J. Sullivan, Sébastien Besteiro

Research output: Contribution to journalLetterpeer-review

4 Scopus citations

Abstract

Environmental and genetic perturbations of endoplasmic reticulum (ER) function can lead to the accumulation of unfolded proteins. In these conditions, eukaryotic cells can activate a complex signaling network called the unfolded protein response (UPR) to reduce ER stress and restore cellular homeostasis. Autophagy, a degradation and recycling process, is part of this response. The parasitic protist Toxoplasma gondii is known to be able to activate the UPR upon ER stress, and we now show that this pathway leads to autophagy activation, supporting the idea of a regulated function for canonical autophagy as part of an integrated stress response in the parasites.

Original languageEnglish (US)
Article numberfnx153
JournalFEMS Microbiology Letters
Volume364
Issue number15
DOIs
StatePublished - Aug 1 2017

Keywords

  • Autophagy
  • EIF2α
  • Endoplasmic reticulum stress
  • Integrated stress response
  • Toxoplasma
  • Unfolded protein response

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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