The distribution of 35S-thiopentone and 14C-phenobarbitone has been studied after intravenous injection in the mouse whole body and in the cat brain, using an auto-radiographic technique. Thirty seconds after injection 35S-thiopentone reached the highest concentration in the brain and liver of the mice, leaving the blood very rapidly. The adipose tissue built up increasing levels of radioactivity up to 20 minutes after the injection of 35S-thiopentone. 14C-phenobarbitone showed a more even distribution in parenchymatous and lean tissues. A rather constant level of radioactivity was present in the blood during 4 hours after the administration of 14C-phenobarbitone. 14C-pheno-barbitone penetrated the blood brain barrier at a much slower rate than 35S-thiopentone. The brain distribution of both compounds was studied in further detail in the cat brain. Experiments with pregnant mice revealed some differences in the placental passage and foetal distribution of these two barbiturates.
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine