Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice

L. G. Mendelsohn, M. C. Smith, V. L. Lucaites, G. A. Kerchner, B. Ghetti

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration (pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalBrain research
Volume458
Issue number2
DOIs
StatePublished - Aug 23 1988

Keywords

  • Cerebellar receptor
  • Insulin-like growth factor II
  • Purkinje cell degeneration mouse
  • Weaver mouse

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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