Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice

Richard B. Lynn, Gao Yuan Cao, Robert V. Considine, Thomas M. Hyde, Jose F. Caro

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

The obese gene product, leptin, is synthesized in adipose tissue and is a circulating factor regulating body weight. To identify the location of leptin receptors in the brain we have performed an autoradiographic study of the binding of [125I]leptin to frozen sections of mouse brain. Dense specific binding of [125I]leptin was found only in the choroid plexus which is located in the dorsal part of the third ventricle and lateral ventricles. Specific binding of [125I]leptin was found in the ob/ob and db/db mice. These findings further our understanding of the sites and mechanism of action of leptin on brain centers regulating body weight.

Original languageEnglish (US)
Pages (from-to)884-889
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume219
Issue number3
DOIs
StatePublished - Feb 27 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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