Autoregulation and neurovascular coupling in the optic nerve head

Daniele Prada, Alon Harris, Giovanna Guidoboni, Brent Siesky, Amelia M. Huang, Julia Arciero

Research output: Contribution to journalReview article

27 Scopus citations


Impairments of autoregulation and neurovascular coupling in the optic nerve head play a critical role in ocular pathologies, especially glaucomatous optic neuropathy. We critically review the literature in the field, integrating results obtained in clinical, experimental, and theoretical studies. We address the mechanisms of autoregulation and neurovascular coupling in the optic nerve head, the current methods used to assess autoregulation-including measurements of optic nerve head blood flow (or volume and velocity)-blood flow data collected in the optic nerve head as pressure or metabolic demand is varied in healthy and pathologic conditions, and the current status and potential of mathematical modeling work to further the understanding of the relationship between ocular blood flow mechanisms and diseases such as glaucoma.

Original languageEnglish (US)
Pages (from-to)164-186
Number of pages23
JournalSurvey of Ophthalmology
Issue number2
StatePublished - Mar 1 2016



  • Autoregulation in the optic nerve head
  • Blood flow regulation modeling
  • Effects of impaired blood flow regulation
  • Glaucoma
  • Mechanical influences on autoregulation
  • Metabolic autoregulation
  • Neurovascular coupling
  • Ocular biomechanics and hemodynamics
  • Optic neuropathies

ASJC Scopus subject areas

  • Ophthalmology

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